Part 2: In vitro cytotoxicity studies of two ML2 complexes (M=Pd, Pt; L=2-cyano-2-isonitroso-N-morpholylacetamide, HMCO)
In recent years, many non-classical groups of Pt-compounds, including complexes with the trans-geometry, polynuclear complexes, and compounds with a variety of extended heterocyclic ligands, were obtained and studied. Part 1 of this work contains the results of our X-ray crystallographic and computa...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 January 2012
|
| In: |
Inorganica chimica acta
Year: 2012, Jahrgang: 385, Pages: 11-20 |
| ISSN: | 0020-1693 |
| DOI: | 10.1016/j.ica.2011.12.004 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.ica.2011.12.004 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0020169311010024 
|
| Verfasserangaben: | Jessica Ratcliff, Paul Durham, Michael Keck, Andriy Mokhir, Nikolay Gerasimchuk |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1571721126 | ||
| 003 | DE-627 | ||
| 005 | 20230426124232.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180405s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ica.2011.12.004 |2 doi | |
| 035 | |a (DE-627)1571721126 | ||
| 035 | |a (DE-576)501721126 | ||
| 035 | |a (DE-599)BSZ501721126 | ||
| 035 | |a (OCoLC)1341001562 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Ratcliff, Jessica |d 1974- |e VerfasserIn |0 (DE-588)142033251 |0 (DE-627)704125080 |0 (DE-576)327441933 |4 aut | |
| 245 | 1 | 0 | |a Part 2 |b In vitro cytotoxicity studies of two ML2 complexes (M=Pd, Pt; L=2-cyano-2-isonitroso-N-morpholylacetamide, HMCO) |c Jessica Ratcliff, Paul Durham, Michael Keck, Andriy Mokhir, Nikolay Gerasimchuk |
| 264 | 1 | |c 3 January 2012 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Im Titel ist "2" in ML2 tiefgestellt | ||
| 500 | |a Gesehen am 05.04.2018 | ||
| 520 | |a In recent years, many non-classical groups of Pt-compounds, including complexes with the trans-geometry, polynuclear complexes, and compounds with a variety of extended heterocyclic ligands, were obtained and studied. Part 1 of this work contains the results of our X-ray crystallographic and computational studies of a group of recently-discovered cytotoxic Pd and Pt complexes of the new cyanoxime ligands HPipCO and HMCO. Here we present the results of our in vitro investigations of two M(MCO)2 (M=Pd, Pt) compounds against two morphologically different human cancer cell lines - epithelial cervical cancer HeLa cells, and WiDr solid tumor colon carcinoma. The Trypan Blue exclusion method was used for the assessment of the complexes’ cytotoxicity. The data indicated a profound in vitro activity of new M(MCO)2 (M=Pd, Pt) complexes, comparable to that of cisplatin, which was used as a positive control. The palladium MCO− complex was found to be consistently slightly more active than its corresponding Pt-analog. Binding of the above compounds to a variety of the DNA was studied by UV-Vis spectroscopy, gel electrophoresis, fluorescent intercalator displacement (FID) assay, and the mitochondria metabolism assay. No evidence of an interaction of either Pd(MCO)2 or Pt(MCO)2 complex with different types of DNA was found, which infers a mechanism of cytotoxicity of these new metallo-cyanoximates different from one of the cisplatin family. This immediately suggests different active species involved in the cellular interactions, as well as different metabolites. Consequently, it implies the absence of the negative side effects so common to the cisplatin family of anticancer drugs. | ||
| 650 | 4 | |a Cyanoximes | |
| 650 | 4 | |a cytotoxicity | |
| 650 | 4 | |a Palladium(II) | |
| 650 | 4 | |a Platinum(II) | |
| 700 | 1 | |a Mokhir, Andriy |d 1973- |e VerfasserIn |0 (DE-588)1020469404 |0 (DE-627)691227683 |0 (DE-576)360499791 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Inorganica chimica acta |d New York, NY [u.a.] : Elsevier, 1967 |g 385(2012), Seite 11-20 |h Online-Ressource |w (DE-627)301510946 |w (DE-600)1484441-2 |w (DE-576)081952694 |x 0020-1693 |7 nnas |a Part 2 In vitro cytotoxicity studies of two ML2 complexes (M=Pd, Pt; L=2-cyano-2-isonitroso-N-morpholylacetamide, HMCO) |
| 773 | 1 | 8 | |g volume:385 |g year:2012 |g pages:11-20 |g extent:10 |a Part 2 In vitro cytotoxicity studies of two ML2 complexes (M=Pd, Pt; L=2-cyano-2-isonitroso-N-morpholylacetamide, HMCO) |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ica.2011.12.004 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0020169311010024 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180405 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 1020469404 |a Mokhir, Andriy |m 1020469404:Mokhir, Andriy |d 120000 |d 120200 |e 120000PM1020469404 |e 120200PM1020469404 |k 0/120000/ |k 1/120000/120200/ |p 4 | ||
| 999 | |a KXP-PPN1571721126 |e 3004970856 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Im Titel ist \"2\" in ML2 tiefgestellt","Gesehen am 05.04.2018"],"language":["eng"],"recId":"1571721126","person":[{"role":"aut","display":"Ratcliff, Jessica","roleDisplay":"VerfasserIn","given":"Jessica","family":"Ratcliff"},{"given":"Andriy","family":"Mokhir","role":"aut","display":"Mokhir, Andriy","roleDisplay":"VerfasserIn"}],"title":[{"title":"Part 2","subtitle":"In vitro cytotoxicity studies of two ML2 complexes (M=Pd, Pt; L=2-cyano-2-isonitroso-N-morpholylacetamide, HMCO)","title_sort":"Part 2"}],"physDesc":[{"extent":"10 S."}],"relHost":[{"origin":[{"publisherPlace":"New York, NY [u.a.]","dateIssuedKey":"1967","publisher":"Elsevier","dateIssuedDisp":"1967-"}],"id":{"issn":["0020-1693"],"zdb":["1484441-2"],"eki":["301510946"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Inorganica chimica acta","title":"Inorganica chimica acta","subtitle":"the international inorganic chemistry journal"}],"note":["Gesehen am 23.04.13"],"disp":"Part 2 In vitro cytotoxicity studies of two ML2 complexes (M=Pd, Pt; L=2-cyano-2-isonitroso-N-morpholylacetamide, HMCO)Inorganica chimica acta","type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"301510946","language":["eng"],"pubHistory":["1.1967 - 363.2010; Vol. 364.2010 -"],"part":{"volume":"385","text":"385(2012), Seite 11-20","extent":"10","year":"2012","pages":"11-20"}}],"name":{"displayForm":["Jessica Ratcliff, Paul Durham, Michael Keck, Andriy Mokhir, Nikolay Gerasimchuk"]},"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"3 January 2012"}],"id":{"doi":["10.1016/j.ica.2011.12.004"],"eki":["1571721126"]}} | ||
| SRT | |a RATCLIFFJEPART23201 | ||