CD44 mediates the catch-bond activated rolling of HEPG2Iso epithelial cancer cells on hyaluronan
The attachment of cancer cells to the endothelium is an essential step during metastatic dissemination. The cell surface receptor CD44 is capable of binding to hyaluronan (HA) produced by tumor cells and by cells of the tumor microenvironment, including blood endothelial cells. Here, we investigated...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 Feb 2017
|
| In: |
Cell adhesion & migration
Year: 2017, Jahrgang: 11, Heft: 5-6, Pages: 476-487 |
| ISSN: | 1933-6926 |
| DOI: | 10.1080/19336918.2016.1260809 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1080/19336918.2016.1260809 Verlag, Volltext: https://doi.org/10.1080/19336918.2016.1260809 
|
| Verfasserangaben: | Maximilian Hanke-Roos, Katharina Fuchs, Stojan Maleschlijski, Jonathan Sleeman, Véronique Orian-Rousseau, Axel Rosenhahn |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1571751378 | ||
| 003 | DE-627 | ||
| 005 | 20220814105429.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180405s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/19336918.2016.1260809 |2 doi | |
| 035 | |a (DE-627)1571751378 | ||
| 035 | |a (DE-576)501751378 | ||
| 035 | |a (DE-599)BSZ501751378 | ||
| 035 | |a (OCoLC)1341001666 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hanke, Maximilian |e VerfasserIn |0 (DE-588)1059731002 |0 (DE-627)798792817 |0 (DE-576)415796687 |4 aut | |
| 245 | 1 | 0 | |a CD44 mediates the catch-bond activated rolling of HEPG2Iso epithelial cancer cells on hyaluronan |c Maximilian Hanke-Roos, Katharina Fuchs, Stojan Maleschlijski, Jonathan Sleeman, Véronique Orian-Rousseau, Axel Rosenhahn |
| 264 | 1 | |c 01 Feb 2017 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.04.2018 | ||
| 520 | |a The attachment of cancer cells to the endothelium is an essential step during metastatic dissemination. The cell surface receptor CD44 is capable of binding to hyaluronan (HA) produced by tumor cells and by cells of the tumor microenvironment, including blood endothelial cells. Here, we investigated the role of CD44 in the interaction between the liver cancer cell line HepG2Iso and HA surfaces. The rolling interaction was quantitatively analyzed using a microfluidic shear force setup. It was found that rolling of the liver cancer cells on HA depends on CD44, which mediates a catch-bond interaction and thus a flow-induced rolling of the cells. Reduction of CD44 expression by means of siRNA, inhibition of the interaction of CD44 with HA by antibody blocking, and treatment with low molecular weight HA inhibited liver cancer cell rolling on HA-coated surfaces. The results not only clearly show the dependency of the shear-induced catch-bond interaction of HepG2Iso cells on CD44 and HA, but also for the first time demonstrate CD44-mediated rolling for epithelium-derived cells that are typically adherent. | ||
| 650 | 4 | |a CD44 | |
| 650 | 4 | |a HepG2Iso | |
| 650 | 4 | |a hyaluronic acid | |
| 650 | 4 | |a metastasis | |
| 650 | 4 | |a rolling | |
| 650 | 4 | |a shear stress | |
| 650 | 4 | |a short chain length hyaluronic acid | |
| 700 | 1 | |a Sleeman, Jonathan P. |d 1965- |e VerfasserIn |0 (DE-588)1026079829 |0 (DE-627)726024554 |0 (DE-576)371076722 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cell adhesion & migration |d London : Taylor & Francis Group, 2007 |g 11(2017), 5-6, Seite 476-487 |h Online-Ressource |w (DE-627)523859813 |w (DE-600)2268518-2 |w (DE-576)286485737 |x 1933-6926 |7 nnas |a CD44 mediates the catch-bond activated rolling of HEPG2Iso epithelial cancer cells on hyaluronan |
| 773 | 1 | 8 | |g volume:11 |g year:2017 |g number:5-6 |g pages:476-487 |g extent:12 |a CD44 mediates the catch-bond activated rolling of HEPG2Iso epithelial cancer cells on hyaluronan |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/19336918.2016.1260809 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.1080/19336918.2016.1260809 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180405 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1026079829 |a Sleeman, Jonathan P. |m 1026079829:Sleeman, Jonathan P. |d 60000 |d 999810 |e 60000PS1026079829 |e 999810PS1026079829 |k 0/60000/ |k 1/60000/999810/ |p 4 | ||
| 998 | |g 1059731002 |a Hanke, Maximilian |m 1059731002:Hanke, Maximilian |d 910000 |d 910100 |e 910000PH1059731002 |e 910100PH1059731002 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1571751378 |e 300521298X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"recId":"1571751378","note":["Gesehen am 05.04.2018"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"family":"Hanke","given":"Maximilian","display":"Hanke, Maximilian","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Sleeman","given":"Jonathan P.","display":"Sleeman, Jonathan P.","roleDisplay":"VerfasserIn","role":"aut"}],"title":[{"title_sort":"CD44 mediates the catch-bond activated rolling of HEPG2Iso epithelial cancer cells on hyaluronan","title":"CD44 mediates the catch-bond activated rolling of HEPG2Iso epithelial cancer cells on hyaluronan"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisher":"Taylor & Francis Group ; Landes Bioscience","dateIssuedKey":"2007","dateIssuedDisp":"2007-","publisherPlace":"London ; New York ; Austin, Tex."}],"id":{"issn":["1933-6926"],"eki":["523859813"],"zdb":["2268518-2"]},"note":["Gesehen am 28.02.2019"],"disp":"CD44 mediates the catch-bond activated rolling of HEPG2Iso epithelial cancer cells on hyaluronanCell adhesion & migration","type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"recId":"523859813","pubHistory":["1.2007 -"],"titleAlt":[{"title":"CAM"},{"title":"Cell adhesion and migration"}],"part":{"extent":"12","volume":"11","text":"11(2017), 5-6, Seite 476-487","issue":"5-6","pages":"476-487","year":"2017"},"title":[{"subtitle":"CAM","title":"Cell adhesion & migration","title_sort":"Cell adhesion & migration"}]}],"physDesc":[{"extent":"12 S."}],"name":{"displayForm":["Maximilian Hanke-Roos, Katharina Fuchs, Stojan Maleschlijski, Jonathan Sleeman, Véronique Orian-Rousseau, Axel Rosenhahn"]},"id":{"doi":["10.1080/19336918.2016.1260809"],"eki":["1571751378"]},"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"01 Feb 2017"}]} | ||
| SRT | |a HANKEMAXIMCD44MEDIAT0120 | ||