Influence of Paclitaxel and Heparin on vitality, proliferation and cytokine production of endometrial cancer cells
Methods This study investigated the effect of paclitaxel (PTX) combined with heparins on the vitality of endometrial cancer cells using viability and cytotoxicity assays. The study also examined whether treatment with paclitaxel and heparin influences cytokine secretion or expression. Results Hepari...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
5.9.2017
|
| In: |
Geburtshilfe und Frauenheilkunde
Year: 2017, Jahrgang: 77, Heft: 10, Pages: 1104-1110 |
| ISSN: | 1438-8804 |
| DOI: | 10.1055/s-0043-119289 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1055/s-0043-119289 Verlag, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-119289 
|
| Verfasserangaben: | Christine Dinkic, Anja Kruse, Marek Zygmunt, Florian Schuetz, Janina Brucker, Joachim Rom, Christof Sohn, Herbert Fluhr |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1571885102 | ||
| 003 | DE-627 | ||
| 005 | 20220814111318.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180410s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1055/s-0043-119289 |2 doi | |
| 035 | |a (DE-627)1571885102 | ||
| 035 | |a (DE-576)501885102 | ||
| 035 | |a (DE-599)BSZ501885102 | ||
| 035 | |a (OCoLC)1341002109 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Dinkic, Christine |e VerfasserIn |0 (DE-588)1122373635 |0 (DE-627)875657680 |0 (DE-576)481259724 |4 aut | |
| 245 | 1 | 0 | |a Influence of Paclitaxel and Heparin on vitality, proliferation and cytokine production of endometrial cancer cells |c Christine Dinkic, Anja Kruse, Marek Zygmunt, Florian Schuetz, Janina Brucker, Joachim Rom, Christof Sohn, Herbert Fluhr |
| 264 | 1 | |c 5.9.2017 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 10.04.2018 | ||
| 520 | |a Methods This study investigated the effect of paclitaxel (PTX) combined with heparins on the vitality of endometrial cancer cells using viability and cytotoxicity assays. The study also examined whether treatment with paclitaxel and heparin influences cytokine secretion or expression. Results Heparin treatment did not influence cell viability, and no influence of heparins in combination with paclitaxel was seen for the evaluated cancer cell lines HEC-1-A, KLE, RL 95-2 and AN3-CA compared to untreated cells. Secretion of the cytokines CCL5, CCL2 and IL-6 increased after paclitaxel treatment in several endometrial cancer cell lines, but no general effect on cytokine secretion was detected after heparin treatment. A significant decrease in CCL5 expression was only detected in KLE cells following treatment with heparin and paclitaxel, and an increase in the expression of CCL5 in RL 95-2 cells. Conclusion Further in-depth studies are needed to investigate the functions of cytokines CCL2, CCL5 and IL-6 in endometrial cancer cells treated with paclitaxel. Although no general effect on cytokine secretion was detected following heparin treatment, a selective modulatory impact could exist. | ||
| 700 | 1 | |a Schütz, Florian |d 1972- |e VerfasserIn |0 (DE-588)12303387X |0 (DE-627)082307229 |0 (DE-576)293528810 |4 aut | |
| 700 | 1 | |a Brucker, Janina |e VerfasserIn |0 (DE-588)1122373708 |0 (DE-627)875657842 |0 (DE-576)48125966X |4 aut | |
| 700 | 1 | |a Rom, Joachim |d 1975- |e VerfasserIn |0 (DE-588)130877018 |0 (DE-627)707590604 |0 (DE-576)298390833 |4 aut | |
| 700 | 1 | |a Sohn, Christof |d 1961- |e VerfasserIn |0 (DE-588)131349287 |0 (DE-627)507642902 |0 (DE-576)298422255 |4 aut | |
| 700 | 1 | |a Fluhr, Herbert |d 1978- |e VerfasserIn |0 (DE-588)13151086X |0 (DE-627)707650542 |0 (DE-576)250372185 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Geburtshilfe und Frauenheilkunde |d Stuttgart : Thieme, 1980 |g 77(2017), 10, Seite 1104-1110 |h Online-Ressource |w (DE-627)324451970 |w (DE-600)2026496-3 |w (DE-576)279447663 |x 1438-8804 |7 nnas |a Influence of Paclitaxel and Heparin on vitality, proliferation and cytokine production of endometrial cancer cells |
| 773 | 1 | 8 | |g volume:77 |g year:2017 |g number:10 |g pages:1104-1110 |g extent:7 |a Influence of Paclitaxel and Heparin on vitality, proliferation and cytokine production of endometrial cancer cells |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1055/s-0043-119289 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-119289 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180410 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 13151086X |a Fluhr, Herbert |m 13151086X:Fluhr, Herbert |d 910000 |d 910400 |e 910000PF13151086X |e 910400PF13151086X |k 0/910000/ |k 1/910000/910400/ | ||
| 998 | |g 131349287 |a Sohn, Christof |m 131349287:Sohn, Christof |d 910000 |d 910400 |e 910000PS131349287 |e 910400PS131349287 |k 0/910000/ |k 1/910000/910400/ | ||
| 998 | |g 130877018 |a Rom, Joachim |m 130877018:Rom, Joachim |d 910000 |d 910400 |e 910000PR130877018 |e 910400PR130877018 |k 0/910000/ |k 1/910000/910400/ | ||
| 998 | |g 1122373708 |a Brucker, Janina |m 1122373708:Brucker, Janina |d 910000 |d 910400 |e 910000PB1122373708 |e 910400PB1122373708 |k 0/910000/ |k 1/910000/910400/ | ||
| 998 | |g 12303387X |a Schütz, Florian |m 12303387X:Schütz, Florian |d 910000 |d 910400 |d 50000 |e 910000PS12303387X |e 910400PS12303387X |e 50000PS12303387X |k 0/910000/ |k 1/910000/910400/ |k 0/50000/ |p 4 | ||
| 998 | |g 1122373635 |a Dinkic, Christine |m 1122373635:Dinkic, Christine |d 910000 |d 910400 |e 910000PD1122373635 |e 910400PD1122373635 |k 0/910000/ |k 1/910000/910400/ |p 1 |x j | ||
| 999 | |a KXP-PPN1571885102 |e 3005545482 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"Stuttgart ; New York, NY","publisher":"Thieme","dateIssuedKey":"1980","dateIssuedDisp":"1980-"}],"id":{"issn":["1438-8804"],"zdb":["2026496-3"],"eki":["324451970"],"doi":["10.1055/s-00000020"]},"disp":"Influence of Paclitaxel and Heparin on vitality, proliferation and cytokine production of endometrial cancer cellsGeburtshilfe und Frauenheilkunde","note":["Erscheint monatlich","Gesehen am 08.11.2024"],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["ger"],"recId":"324451970","pubHistory":["Nachgewiesen 40.1980 -"],"part":{"pages":"1104-1110","issue":"10","year":"2017","extent":"7","volume":"77","text":"77(2017), 10, Seite 1104-1110"},"titleAlt":[{"title":"GEBFRA"}],"title":[{"title_sort":"Geburtshilfe und Frauenheilkunde","title":"Geburtshilfe und Frauenheilkunde"}]}],"physDesc":[{"extent":"7 S."}],"name":{"displayForm":["Christine Dinkic, Anja Kruse, Marek Zygmunt, Florian Schuetz, Janina Brucker, Joachim Rom, Christof Sohn, Herbert Fluhr"]},"id":{"eki":["1571885102"],"doi":["10.1055/s-0043-119289"]},"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"5.9.2017"}],"language":["eng"],"recId":"1571885102","note":["Gesehen am 10.04.2018"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"family":"Dinkic","given":"Christine","roleDisplay":"VerfasserIn","display":"Dinkic, Christine","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Schütz, Florian","given":"Florian","family":"Schütz"},{"roleDisplay":"VerfasserIn","display":"Brucker, Janina","role":"aut","family":"Brucker","given":"Janina"},{"role":"aut","display":"Rom, Joachim","roleDisplay":"VerfasserIn","given":"Joachim","family":"Rom"},{"family":"Sohn","given":"Christof","display":"Sohn, Christof","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"Fluhr, Herbert","roleDisplay":"VerfasserIn","given":"Herbert","family":"Fluhr"}],"title":[{"title":"Influence of Paclitaxel and Heparin on vitality, proliferation and cytokine production of endometrial cancer cells","title_sort":"Influence of Paclitaxel and Heparin on vitality, proliferation and cytokine production of endometrial cancer cells"}]} | ||
| SRT | |a DINKICCHRIINFLUENCEO5920 | ||