Subventricular zone-derived neuroblasts use vasculature as a scaffold to migrate radially to the cortex in neonatal mice
Neurons continue to be generated in the subventricular zone (SVZ) throughout postnatal development and adulthood in rodents. Whereas in adults, virtually all neuroblasts migrate tangentially to the olfactory bulb via the rostral migratory stream (RMS), in neonates, a substantial fraction migrate rad...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 2012
|
| In: |
Cerebral cortex
Year: 2012, Jahrgang: 22, Heft: 10, Pages: 2285-2296 |
| ISSN: | 1460-2199 |
| DOI: | 10.1093/cercor/bhr302 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1093/cercor/bhr302 Verlag, Volltext: https://academic.oup.com/cercor/article/22/10/2285/287088 
|
| Verfasserangaben: | Corentin Le Magueresse, Christine Bark, Marina Eliava, Sergey Khrulev, Hannah Monyer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1571922032 | ||
| 003 | DE-627 | ||
| 005 | 20220814111742.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180411s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/cercor/bhr302 |2 doi | |
| 035 | |a (DE-627)1571922032 | ||
| 035 | |a (DE-576)501922032 | ||
| 035 | |a (DE-599)BSZ501922032 | ||
| 035 | |a (OCoLC)1341002183 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Le Magueresse, Corentin |e VerfasserIn |0 (DE-588)1155874498 |0 (DE-627)1018353461 |0 (DE-576)501919333 |4 aut | |
| 245 | 1 | 0 | |a Subventricular zone-derived neuroblasts use vasculature as a scaffold to migrate radially to the cortex in neonatal mice |c Corentin Le Magueresse, Christine Bark, Marina Eliava, Sergey Khrulev, Hannah Monyer |
| 264 | 1 | |c October 2012 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.04.2018 | ||
| 520 | |a Neurons continue to be generated in the subventricular zone (SVZ) throughout postnatal development and adulthood in rodents. Whereas in adults, virtually all neuroblasts migrate tangentially to the olfactory bulb via the rostral migratory stream (RMS), in neonates, a substantial fraction migrate radially through the corpus callosum (CC) to the cortex. Mechanisms of radial cortical migration have remained unknown. We investigated this by taking recourse to enhanced green fluorescent protein (EGFP)-labeled neuroblasts in the CC and deep cortical layers of neonatal mice and found that they are frequently located adjacent to vasculature. Using time-lapse 2-photon microscopy in acute brain slices, we demonstrate that EGFP-labeled neuroblasts migrate along blood vessels. Although in close proximity to blood vessels, migrating neuroblasts are separated from endothelial cells by 1-2 layers of astrocytic processes, as revealed by electron microscopal studies of retrovirally labeled postnatally born cells. We propose that 2 factors could contribute to the decline of radial migration to the cortex during postnatal development, namely the establishment of a glial sheath delineating the RMS and a gradual decrease in the density of blood vessels in the CC. Together, our data provide evidence for a new mode of radial cortical migration of SVZ-generated neurons involving vasculature and astrocytes. | ||
| 700 | 1 | |a Bark, Christine |d 1978- |e VerfasserIn |0 (DE-588)133927997 |0 (DE-627)558737641 |0 (DE-576)278391354 |4 aut | |
| 700 | 1 | |a Eliava, Marina |e VerfasserIn |0 (DE-588)1155877322 |0 (DE-627)1018356584 |0 (DE-576)501921699 |4 aut | |
| 700 | 1 | |a Khrulev, Sergey |d 1979- |e VerfasserIn |0 (DE-588)1018033319 |0 (DE-627)690496559 |0 (DE-576)354333305 |4 aut | |
| 700 | 1 | |a Monyer, Hannah |d 1957- |e VerfasserIn |0 (DE-588)1012792374 |0 (DE-627)662740416 |0 (DE-576)345945514 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cerebral cortex |d Oxford : Oxford Univ. Press, 1991 |g 22(2012), 10, Seite 2285-2296 |h Online-Ressource |w (DE-627)300896948 |w (DE-600)1483485-6 |w (DE-576)088704572 |x 1460-2199 |7 nnas |a Subventricular zone-derived neuroblasts use vasculature as a scaffold to migrate radially to the cortex in neonatal mice |
| 773 | 1 | 8 | |g volume:22 |g year:2012 |g number:10 |g pages:2285-2296 |g extent:12 |a Subventricular zone-derived neuroblasts use vasculature as a scaffold to migrate radially to the cortex in neonatal mice |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/cercor/bhr302 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://academic.oup.com/cercor/article/22/10/2285/287088 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180411 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 1012792374 |a Monyer, Hannah |m 1012792374:Monyer, Hannah |d 910000 |d 911100 |e 910000PM1012792374 |e 911100PM1012792374 |k 0/910000/ |k 1/910000/911100/ |p 6 |y j | ||
| 998 | |g 1018033319 |a Khrulev, Sergey |m 1018033319:Khrulev, Sergey |d 910000 |d 911100 |e 910000PK1018033319 |e 911100PK1018033319 |k 0/910000/ |k 1/910000/911100/ |p 5 | ||
| 998 | |g 1155877322 |a Eliava, Marina |m 1155877322:Eliava, Marina |d 910000 |d 911100 |e 910000PE1155877322 |e 911100PE1155877322 |k 0/910000/ |k 1/910000/911100/ |p 4 | ||
| 998 | |g 133927997 |a Bark, Christine |m 133927997:Bark, Christine |d 910000 |d 910600 |e 910000PB133927997 |e 910600PB133927997 |k 0/910000/ |k 1/910000/910600/ |p 3 | ||
| 998 | |g 1155874498 |a Le Magueresse, Corentin |m 1155874498:Le Magueresse, Corentin |d 910000 |d 911100 |e 910000PL1155874498 |e 911100PL1155874498 |k 0/910000/ |k 1/910000/911100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1571922032 |e 3005819701 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"part":{"volume":"22","pages":"2285-2296","text":"22(2012), 10, Seite 2285-2296","year":"2012","extent":"12","issue":"10"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Cerebral cortex","title":"Cerebral cortex"}],"origin":[{"publisherPlace":"Oxford","dateIssuedDisp":"1991-","dateIssuedKey":"1991","publisher":"Oxford Univ. Press"}],"id":{"issn":["1460-2199"],"zdb":["1483485-6"],"eki":["300896948"]},"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"300896948","pubHistory":["1.1991 -"],"note":["Gesehen am 05.01.2017"],"disp":"Subventricular zone-derived neuroblasts use vasculature as a scaffold to migrate radially to the cortex in neonatal miceCerebral cortex"}],"title":[{"title_sort":"Subventricular zone-derived neuroblasts use vasculature as a scaffold to migrate radially to the cortex in neonatal mice","title":"Subventricular zone-derived neuroblasts use vasculature as a scaffold to migrate radially to the cortex in neonatal mice"}],"person":[{"given":"Corentin","display":"Le Magueresse, Corentin","family":"Le Magueresse","role":"aut"},{"family":"Bark","display":"Bark, Christine","given":"Christine","role":"aut"},{"role":"aut","given":"Marina","family":"Eliava","display":"Eliava, Marina"},{"display":"Khrulev, Sergey","family":"Khrulev","given":"Sergey","role":"aut"},{"role":"aut","given":"Hannah","family":"Monyer","display":"Monyer, Hannah"}],"physDesc":[{"extent":"12 S."}],"id":{"eki":["1571922032"],"doi":["10.1093/cercor/bhr302"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"October 2012"}],"note":["Gesehen am 11.04.2018"],"recId":"1571922032","name":{"displayForm":["Corentin Le Magueresse, Christine Bark, Marina Eliava, Sergey Khrulev, Hannah Monyer"]}} | ||
| SRT | |a LEMAGUERESSUBVENTRIC2012 | ||