Multidrug‐resistant organisms in allogeneic hematopoietic cell transplantation
Abstract: Objective multidrug-resistant organisms (MDRO) are a challenge in allogeneic hematopoietic cell transplantation (HCT). However, in the literature there is no comprehensive analysis on MDRO in HCT. In this retrospective, single-center analysis, we appraised prevalence and clinical impact of...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
30 January 2017
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| In: |
European journal of haematology
Year: 2017, Volume: 98, Issue: 5, Pages: 485-492 |
| ISSN: | 1600-0609 |
| DOI: | 10.1111/ejh.12859 |
| Online Access: | Verlag, kostenfrei registrierungspflichtig, Volltext: http://dx.doi.org/10.1111/ejh.12859 Verlag, kostenfrei registrierungspflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ejh.12859 
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| Author Notes: | Daniela Heidenreich, Sebastian Kreil, Florian Nolte, Wolf K. Hofmann, Thomas Miethke,Stefan A. Klein |
| Summary: | Abstract: Objective multidrug-resistant organisms (MDRO) are a challenge in allogeneic hematopoietic cell transplantation (HCT). However, in the literature there is no comprehensive analysis on MDRO in HCT. In this retrospective, single-center analysis, we appraised prevalence and clinical impact of MDRO in 98 consecutive allogeneic HCT patients. Method: Prior to the conditioning (baseline) and whenever clinically indicated patients underwent a full screening for MDRO (stool and urine cultures, swabs from several body regions). Results: It turned out that 26 patients were colonized by 33 MDRO, either at baseline (n=16) or at any other time until day 100 post?transplantation. Of these 26 patients, eight developed an infection with MDRO, four of them by 4MRGN Pseudomonas aeruginosa, and three of them died MDRO-related. However, there was no significant difference between MDRO-colonized and non-colonized patients regarding overall survival (OS) and non-relapse-mortality (NRM). There was only a trend toward a higher NRM in patients already colonized by MDRO at baseline. This was due to the high NRM in multidrug-resistant P. aeruginosa-colonized patients. Conclusion: In summary, colonization with MDRO other than P. aeruginosa had no negative impact on NRM and OS. Patients colonized by multidrug-resistant P. aeruginosa had a dismal outcome. HCT of these patients should be considered with care. Screening for MDRO in the pretransplant work-up is suggested. |
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| Item Description: | Gesehen am 12.04.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1600-0609 |
| DOI: | 10.1111/ejh.12859 |