Calcium handling and atrial fibrillation
Summary: Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia in the clinical setting. It is associated with substantial cardiovascular morbidity and mortality. Recent research has indicated that abnormal Ca2+ handling plays a critical role in the induction and maintenance of...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 June 2012
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| In: |
Wiener medizinische Wochenschrift
Year: 2012, Jahrgang: 162, Heft: 13-14, Pages: 287-291 |
| ISSN: | 1563-258X |
| DOI: | 10.1007/s10354-012-0109-9 |
| Online-Zugang: | Verlag, kostenfrei registrierungspflichtig, Volltext: http://dx.doi.org/10.1007/s10354-012-0109-9 Verlag, kostenfrei registrierungspflichtig, Volltext: https://link.springer.com/article/10.1007/s10354-012-0109-9 
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| Verfasserangaben: | Jordi Heijman, Niels Voigt, Stanley Nattel, Dobromir Dobrev |
| Zusammenfassung: | Summary: Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia in the clinical setting. It is associated with substantial cardiovascular morbidity and mortality. Recent research has indicated that abnormal Ca2+ handling plays a critical role in the induction and maintenance of AF, contributing to ectopic activity, AF-maintaining reentry circuits and related prothrombotic atrial hypocontractility. The AF-specific Ca2+-handling abnormalities may constitute viable therapeutic approaches to treat AF. Here, we review the causes, consequences, and therapeutic implications of altered atrial Ca2+ handling for AF pathophysiology. |
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| Beschreibung: | Gesehen am 12.04.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1563-258X |
| DOI: | 10.1007/s10354-012-0109-9 |