ABC transporter function and regulation at the blood-spinal cord barrier
We present here an initial characterization of ATP binding cassette (ABC) transporter function and regulation at the blood-spinal cord barrier. We isolated capillaries from rat spinal cords and studied transport function using a confocal microscopy-based assay and protein expression using western bl...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
April 4, 2012
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| In: |
Journal of cerebral blood flow & metabolism
Year: 2012, Volume: 32, Issue: 8, Pages: 1559-1566 |
| ISSN: | 1559-7016 |
| DOI: | 10.1038/jcbfm.2012.47 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1038/jcbfm.2012.47 Verlag, Volltext: https://doi.org/10.1038/jcbfm.2012.47 
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| Author Notes: | Christopher R Campos, Christian Schröter, Xueqian Wang, David S Miller |
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| 520 | |a We present here an initial characterization of ATP binding cassette (ABC) transporter function and regulation at the blood-spinal cord barrier. We isolated capillaries from rat spinal cords and studied transport function using a confocal microscopy-based assay and protein expression using western blots. These capillaries exhibited transport function and protein expression of P-glycoprotein (Abcb1), multidrug resistance protein 2 (Mrp2, Abcc2), and breast cancer-related protein (Bcrp, Abcg2). Exposing isolated capillaries to dioxin (activates aryl hydrocarbon receptor) increased transport mediated by all three transporters. Brain and spinal cord capillaries from dioxin-dosed rats exhibited increased P-glycoprotein-mediated transport and increased protein expression for all three ABC transporters. These findings indicate similar ABC transporter expression, function, and regulation at the blood-spinal cord and blood-brain barriers. | ||
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