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Chimeric antigen receptor transduced T cells: tuning up for the next generation

Chimeric antigen receptor (CAR) T cell therapy has recently achieved impressive clinical outcome in patients with CD19?positive hematologic malignancies. Extrapolation of CAR T cell treatment to solid tumors, however, has not yet yielded similar results. This might be due to intrinsic causes, e.g. i...

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Main Authors: Schubert, Maria-Luisa (Author) , Hoffmann, Jean-Marc (Author) , Dreger, Peter (Author) , Müller-Tidow, Carsten (Author) , Schmitt, Michael (Author)
Format: Article (Journal)
Language:English
Published: 2018
In: International journal of cancer
Year: 2017, Volume: 142, Issue: 9, Pages: 1738-1747
ISSN:1097-0215
DOI:10.1002/ijc.31147
Online Access:Verlag, Volltext: http://dx.doi.org/10.1002/ijc.31147
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.31147
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Author Notes:Maria-Luisa Schubert, Jean-Marc Hoffmann, Peter Dreger, Carsten Müller-Tidow and Michael Schmitt

MARC

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