Glomerular diseases: podocyte hypertrophy mismatch and glomerular disease
Cell hypertrophy is the only mechanism by which podocytes can cope with increased functional demands, whereas other glomerular cells can adapt by cell proliferation. In the setting of systemically stimulated glomerular growth, a 'mismatch' of inadequate podocyte hypertrophy and overall glo...
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| Main Author: | |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
25 September 2012
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| In: |
Nature reviews. Nephrology
Year: 2012, Volume: 8, Issue: 11, Pages: 618-619 |
| ISSN: | 1759-507X |
| DOI: | 10.1038/nrneph.2012.198 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1038/nrneph.2012.198 Verlag, Volltext: https://www.nature.com/articles/nrneph.2012.198 
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| Author Notes: | Wilhelm Kriz |
| Summary: | Cell hypertrophy is the only mechanism by which podocytes can cope with increased functional demands, whereas other glomerular cells can adapt by cell proliferation. In the setting of systemically stimulated glomerular growth, a 'mismatch' of inadequate podocyte hypertrophy and overall glomerular growth may lead to podocyte loss and development of focal segmental glomerulosclerosis. |
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| Item Description: | Gesehen am 16.04.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1759-507X |
| DOI: | 10.1038/nrneph.2012.198 |