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Ion channel expression and characterization in human induced pluripotent stem cell-derived cardiomyocytes

Background. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are providing new possibilities for the biological study, cell therapies, and drug discovery. However, the ion channel expression and functions as well as regulations in hiPSC-CMs still need to be fully characterized....

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Hauptverfasser: Zhao, Zhihan (VerfasserIn) , Lan, Huan (VerfasserIn) , El-Battrawy, Ibrahim (VerfasserIn) , Buljubasic, Fanis (VerfasserIn) , Sattler, Katherine (VerfasserIn) , Yücel, Gökhan (VerfasserIn) , Lang, Siegfried (VerfasserIn) , Utikal, Jochen (VerfasserIn) , Wieland, Thomas (VerfasserIn) , Borggrefe, Martin (VerfasserIn) , Zhou, Xiao-Bo (VerfasserIn) , Akın, Ibrahim (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 8 January 2018
In: Stem cells international

ISSN:1687-9678
DOI:10.1155/2018/6067096
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1155/2018/6067096
Verlag, kostenfrei, Volltext: https://www.hindawi.com/journals/sci/2018/6067096/
Volltext
Verfasserangaben:Zhihan Zhao, Huan Lan, Ibrahim El-Battrawy, Xin Li, Fanis Buljubasic, Katherine Sattler, Gökhan Yücel, Siegfried Lang, Malte Tiburcy, Wolfram-Hubertus Zimmermann, Lukas Cyganek, Jochen Utikal, Thomas Wieland, Martin Borggrefe, Xiao-Bo Zhou, and Ibrahim Akin
Beschreibung
Zusammenfassung:Background. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are providing new possibilities for the biological study, cell therapies, and drug discovery. However, the ion channel expression and functions as well as regulations in hiPSC-CMs still need to be fully characterized. Methods. Cardiomyocytes were derived from hiPS cells that were generated from two healthy donors. qPCR and patch clamp techniques were used for the study. Results. In addition to the reported ion channels, INa, ICa-L, ICa-T, If, INCX, IK1, Ito, IKr, IKs IKATP, IK-pH, ISK1-3, and ISK4, we detected both the expression and currents of ACh-activated (KACh) and Na
Beschreibung:Gesehen am 17.04.2018
Beschreibung:Online Resource
ISSN:1687-9678
DOI:10.1155/2018/6067096

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