Global slowing of network oscillations in mouse neocortex by diazepam
Benzodiazepines have a broad spectrum of clinical applications including sedation, anti-anxiety, and anticonvulsive therapy. At the cellular level, benzodiazepines are allosteric modulators of GABA(A) receptors; they increase the efficacy of inhibition in neuronal networks by prolonging the duration...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2013
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| In: |
Neuropharmacology
Year: 2013, Volume: 65, Pages: 123-133 |
| ISSN: | 1873-7064 |
| DOI: | 10.1016/j.neuropharm.2012.09.014 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.neuropharm.2012.09.014 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0028390812004868 Verlag, Volltext: http://dx.doi.org/10.1016/j.neuropharm.2012.09.014 
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| Author Notes: | Claudia Scheffzük, Valeriy I. Kukushka, Alexei L. Vyssotski, Andreas Draguhn, Adriano B.L. Tort, Jurij Brankačk |
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| 245 | 1 | 0 | |a Global slowing of network oscillations in mouse neocortex by diazepam |c Claudia Scheffzük, Valeriy I. Kukushka, Alexei L. Vyssotski, Andreas Draguhn, Adriano B.L. Tort, Jurij Brankačk |
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| 520 | |a Benzodiazepines have a broad spectrum of clinical applications including sedation, anti-anxiety, and anticonvulsive therapy. At the cellular level, benzodiazepines are allosteric modulators of GABA(A) receptors; they increase the efficacy of inhibition in neuronal networks by prolonging the duration of inhibitory postsynaptic potentials. This mechanism of action predicts that benzodiazepines reduce the frequency of inhibition-driven network oscillations, consistent with observations from human and animal EEG. However, most of existing data are restricted to frequency bands below ∼30 Hz. Recent data suggest that faster cortical network rhythms are critically involved in several behavioral and cognitive tasks. We therefore analyzed diazepam effects on a large range of cortical network oscillations in freely moving mice, including theta (4-12 Hz), gamma (40-100 Hz) and fast gamma (120-160 Hz) oscillations. We also investigated diazepam effects over the coupling between theta phase and the amplitude fast oscillations. We report that diazepam causes a global slowing of oscillatory activity in all frequency domains. Oscillation power was changed differently for each frequency domain, with characteristic differences between active wakefulness, slow-wave sleep and REM sleep. Cross-frequency coupling strength, in contrast, was mostly unaffected by diazepam. Such state- and frequency-dependent actions of benzodiazepines on cortical network oscillations may be relevant for their specific cognitive effects. They also underline the strong interaction between local network oscillations and global brain states. | ||
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