Coculture with hematopoietic stem cells protects cardiomyocytes against apoptosis via paracrine activation of AKT
Previous experimental studies concluded that stem cells (SC) may exert their beneficial effects on the ischemic heart by paracrine activation of antiapoptotic pathways. In order to identify potential cardioprotective mediators, we performed a systematic analysis of the differential gene expression o...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
6 June 2012
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| In: |
Journal of translational medicine
Year: 2012, Jahrgang: 10 |
| ISSN: | 1479-5876 |
| DOI: | 10.1186/1479-5876-10-115 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1186/1479-5876-10-115 Verlag, Volltext: https://doi.org/10.1186/1479-5876-10-115 
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| Verfasserangaben: | Mark Rosenberg, Matthias Lutz, Constantin Kühl, Rainer Will, Volker Eckstein, Jutta Krebs, Hugo A. Katus and Norbert Frey |
MARC
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| 520 | |a Previous experimental studies concluded that stem cells (SC) may exert their beneficial effects on the ischemic heart by paracrine activation of antiapoptotic pathways. In order to identify potential cardioprotective mediators, we performed a systematic analysis of the differential gene expression of hematopoietic SC after coculture with cardiomyocytes (CM). | ||
| 650 | 4 | |a Apoptosis | |
| 650 | 4 | |a Cardiomyocytes | |
| 650 | 4 | |a Paracrine | |
| 650 | 4 | |a Stem cells | |
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