Cover Image

Resistance training as supportive measure in advanced cancer patients undergoing TKI therapy: a controlled feasibility trial

Purpose: While there is growing evidence for positive effects of progressive resistance training in curatively treated cancer patients, data on advanced cancer patients are scarce. This pilot study aimed at investigating for the first time feasibility and effects of progressive resistance training i...

Full description

Saved in:
Bibliographic Details
Main Authors: Rosenberger, Friederike (Author) , Wiskemann, Joachim (Author) , Vallet, Sonia (Author) , Haag, Georg Martin (Author) , Schembri, Emanuel (Author) , Jäger, Dirk (Author) , Grüllich, Carsten (Author)
Format: Article (Journal)
Language:English
Published: December 2017
In: Supportive care in cancer
Year: 2017, Volume: 25, Issue: 12, Pages: 3655-3664
ISSN:1433-7339
DOI:10.1007/s00520-017-3788-3
Online Access:Verlag, Volltext: http://dx.doi.org/10.1007/s00520-017-3788-3
Verlag, Volltext: https://link.springer.com/article/10.1007/s00520-017-3788-3
Get full text
Author Notes:F. Rosenberger, J. Wiskemann, S. Vallet, G. M. Haag, E. Schembri, D. Jäger, C. Grüllich
Description
Summary:Purpose: While there is growing evidence for positive effects of progressive resistance training in curatively treated cancer patients, data on advanced cancer patients are scarce. This pilot study aimed at investigating for the first time feasibility and effects of progressive resistance training in advanced cancer patients undergoing tyrosine kinase inhibitor (TKI) therapy.MethodsPatients starting a TKI-based anti-tumor therapy were assigned to a resistance training group (RT, 12 weeks of progressive machine-based resistance training 2×/week) or a control group (CON, treatment as usual) until 10 patients had finished in each group (RT 80% males, 90% renal cell carcinoma, 65 ± 11 years, CON 80% males, 70% renal cell carcinoma, 61 ± 6 years). Primary endpoint was feasibility. Furthermore, fatigue (MFI), quality of life (QoL, EORTC QLQC30), and muscle strength were assessed. Testing occurred at baseline and after 12 weeks.Results: Training was feasible in 9 out of 10 participants and no serious adverse events occurred. It had beneficial effects on muscle strength (maximum voluntary isometric contraction of the quadriceps: RT +11 ± 9 Nm, CON −13 ± 25 Nm, p = 0.005), but not on fatigue (general fatigue score RT +0.3 ± 4.1, CON -1.5 ± 3.0, p = 0.223) or QoL (global QoL score RT −5.6 ± 16.1, CON −2.0 ± 18.2, p = 0.617).Conclusions: Progressive machine-based resistance training appears feasible in the majority of advanced cancer patients undergoing TKI therapy. However, its positive effects on muscle strength do not seem to be associated with positive effects on fatigue or quality of life. Future studies should therefore compare whether home-based training is more beneficial for patient-reported outcomes.Trial registration NCT01645150
Item Description:Gesehen am 18.04.2018
Physical Description:Online Resource
ISSN:1433-7339
DOI:10.1007/s00520-017-3788-3

Similar Items