An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors
In many cancers, spreading and the formation of metastasis involve the coordinated migration of many cells. An interdisciplinary team of researchers from Heidelberg and Frankfurt studied the collective movement of cultured lung cancer cells subject to chemical stimulation. Based on extensive data an...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
03 March 2017
|
| In: |
npj Systems biology and applications
Year: 2017, Volume: 3, Issue: 1, Pages: 5 |
| ISSN: | 2056-7189 |
| DOI: | 10.1038/s41540-017-0006-3 |
| Online Access: | Verlag, LF, Volltext: http://dx.doi.org/10.1038/s41540-017-0006-3 Verlag, LF, Volltext: https://www.nature.com/articles/s41540-017-0006-3 
|
| Author Notes: | Damian Stichel, Alistair M. Middleton, Benedikt F. Müller, Sofia Depner, Ursula Klingmüller, Kai Breuhahn and Franziska Matthäus |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1572142081 | ||
| 003 | DE-627 | ||
| 005 | 20230426124247.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180418s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41540-017-0006-3 |2 doi | |
| 035 | |a (DE-627)1572142081 | ||
| 035 | |a (DE-576)502142081 | ||
| 035 | |a (DE-599)BSZ502142081 | ||
| 035 | |a (OCoLC)1341007239 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Stichel, Damian |e VerfasserIn |0 (DE-588)1078124507 |0 (DE-627)838010059 |0 (DE-576)359423566 |4 aut | |
| 245 | 1 | 3 | |a An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors |c Damian Stichel, Alistair M. Middleton, Benedikt F. Müller, Sofia Depner, Ursula Klingmüller, Kai Breuhahn and Franziska Matthäus |
| 264 | 1 | |c 03 March 2017 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 01.09.2020 | ||
| 520 | |a In many cancers, spreading and the formation of metastasis involve the coordinated migration of many cells. An interdisciplinary team of researchers from Heidelberg and Frankfurt studied the collective movement of cultured lung cancer cells subject to chemical stimulation. Based on extensive data analysis a mathematical model was developed to explain the variety of migration behaviors observed under different treatments. The model describes the mechanics of compression, stretch, cell elasticity and force-regulated active motion—which in sum lead to coordination within large cell groups. Simulations demonstrate how these mechanical features affect cell coordination and collective behavior. In tests of potential medical treatment strategies, the model can be used to predict the effects of the drug on specific mechanical properties of single cells. | ||
| 700 | 1 | |a Middleton, Alistair |e VerfasserIn |0 (DE-588)1115191179 |0 (DE-627)869496085 |0 (DE-576)477633714 |4 aut | |
| 700 | 1 | |a Müller, Benedikt |e VerfasserIn |0 (DE-588)1075739713 |0 (DE-627)833656244 |0 (DE-576)44460684X |4 aut | |
| 700 | 1 | |a Depner, Sofia |d 1968- |e VerfasserIn |0 (DE-588)132021374 |0 (DE-627)516845128 |0 (DE-576)298898012 |4 aut | |
| 700 | 1 | |a Klingmüller, Ursula |d 1964- |e VerfasserIn |0 (DE-588)1098573455 |0 (DE-627)857742876 |0 (DE-576)46917014X |4 aut | |
| 700 | 1 | |a Breuhahn, Kai |d 1969- |e VerfasserIn |0 (DE-588)122803329 |0 (DE-627)082164959 |0 (DE-576)293427364 |4 aut | |
| 700 | 1 | |a Matthäus, Franziska |d 1975- |e VerfasserIn |0 (DE-588)1053291493 |0 (DE-627)789749823 |0 (DE-576)409030031 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t npj Systems biology and applications |d London : Nature Publ. Group, 2015 |g 3(2017), 1, Seite 5 |h Online-Ressource |w (DE-627)842610146 |w (DE-600)2841868-2 |w (DE-576)452959721 |x 2056-7189 |7 nnas |a An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors |
| 773 | 1 | 8 | |g volume:3 |g year:2017 |g number:1 |g pages:5 |g extent:10 |a An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41540-017-0006-3 |x Verlag |x Resolving-System |y LF |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41540-017-0006-3 |x Verlag |y LF |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180418 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1098573455 |a Klingmüller, Ursula |m 1098573455:Klingmüller, Ursula |d 140000 |e 140000PK1098573455 |k 0/140000/ |p 5 | ||
| 998 | |g 132021374 |a Depner, Sofia |m 132021374:Depner, Sofia |d 140000 |e 140000PD132021374 |k 0/140000/ |p 4 | ||
| 998 | |g 1053291493 |a Matthäus, Franziska |m 1053291493:Matthäus, Franziska |p 7 |y j | ||
| 998 | |g 122803329 |a Breuhahn, Kai |m 122803329:Breuhahn, Kai |d 910000 |d 912000 |e 910000PB122803329 |e 912000PB122803329 |k 0/910000/ |k 1/910000/912000/ |p 6 | ||
| 998 | |g 1075739713 |a Müller, Benedikt |m 1075739713:Müller, Benedikt |p 3 | ||
| 998 | |g 1115191179 |a Middleton, Alistair |m 1115191179:Middleton, Alistair |p 2 | ||
| 998 | |g 1078124507 |a Stichel, Damian |m 1078124507:Stichel, Damian |d 700000 |d 716000 |e 700000PS1078124507 |e 716000PS1078124507 |k 0/700000/ |k 1/700000/716000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1572142081 |e 3006389409 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"name":{"displayForm":["Damian Stichel, Alistair M. Middleton, Benedikt F. Müller, Sofia Depner, Ursula Klingmüller, Kai Breuhahn and Franziska Matthäus"]},"title":[{"title_sort":"individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors","title":"An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors"}],"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"03 March 2017"}],"id":{"eki":["1572142081"],"doi":["10.1038/s41540-017-0006-3"]},"person":[{"given":"Damian","display":"Stichel, Damian","role":"aut","family":"Stichel"},{"given":"Alistair","display":"Middleton, Alistair","role":"aut","family":"Middleton"},{"given":"Benedikt","family":"Müller","role":"aut","display":"Müller, Benedikt"},{"display":"Depner, Sofia","role":"aut","family":"Depner","given":"Sofia"},{"role":"aut","display":"Klingmüller, Ursula","family":"Klingmüller","given":"Ursula"},{"given":"Kai","display":"Breuhahn, Kai","role":"aut","family":"Breuhahn"},{"given":"Franziska","family":"Matthäus","display":"Matthäus, Franziska","role":"aut"}],"note":["Gesehen am 01.09.2020"],"language":["eng"],"relHost":[{"origin":[{"dateIssuedDisp":"September 2015-","publisherPlace":"London","publisher":"Nature Publ. Group"}],"part":{"issue":"1","volume":"3","extent":"10","text":"3(2017), 1, Seite 5","year":"2017","pages":"5"},"id":{"issn":["2056-7189"],"eki":["842610146"],"zdb":["2841868-2"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title_sort":"npj Systems biology and applications","title":"npj Systems biology and applications"}],"disp":"An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factorsnpj Systems biology and applications","recId":"842610146","physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"pubHistory":["28 September 2015-"]}],"recId":"1572142081","physDesc":[{"extent":"10 S."}]} | ||
| SRT | |a STICHELDAMINDIVIDUAL0320 | ||