Cover Image

Glycyrrhetinic acid antagonizes pressure-induced venous remodeling in mice

Development of spider veins is caused by the remodeling of veins located in the upper dermis and promoted by risk factors such as obesity or pregnancy that chronically increase venous pressure. We have repeatedly shown that the pressure-induced increase in biomechanical wall stress is sufficient to...

Full description

Saved in:
Bibliographic Details
Main Authors: Kuk, Hanna (Author) , Arnold, Caroline (Author) , Wagner, Andreas H. (Author) , Hecker, Markus (Author) , Sticht, Carsten (Author) , Korff, Thomas (Author)
Format: Article (Journal)
Language:English
Published: 04 April 2018
In: Frontiers in physiology
Year: 2018, Volume: 9
ISSN:1664-042X
DOI:10.3389/fphys.2018.00320
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.3389/fphys.2018.00320
Verlag, kostenfrei, Volltext: https://www.frontiersin.org/articles/10.3389/fphys.2018.00320/full
Get full text
Author Notes:Hanna Kuk, Caroline Arnold, Andreas H. Wagner, Markus Hecker, Carsten Sticht and Thomas Korff

MARC

LEADER 00000caa a2200000 c 4500
001 1572219750
003 DE-627
005 20210815110751.0
007 cr uuu---uuuuu
008 180420s2018 xx |||||o 00| ||eng c
024 7 |a 10.3389/fphys.2018.00320  |2 doi 
035 |a (DE-627)1572219750 
035 |a (DE-576)502219750 
035 |a (DE-599)BSZ502219750 
035 |a (OCoLC)1263973842 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Kuk, Hanna  |e VerfasserIn  |0 (DE-588)1150443944  |0 (DE-627)1010762923  |0 (DE-576)497075784  |4 aut 
245 1 0 |a Glycyrrhetinic acid antagonizes pressure-induced venous remodeling in mice  |c Hanna Kuk, Caroline Arnold, Andreas H. Wagner, Markus Hecker, Carsten Sticht and Thomas Korff 
264 1 |c 04 April 2018 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 20.04.2018 
520 |a Development of spider veins is caused by the remodeling of veins located in the upper dermis and promoted by risk factors such as obesity or pregnancy that chronically increase venous pressure. We have repeatedly shown that the pressure-induced increase in biomechanical wall stress is sufficient to evoke the formation of enlarged corkscrew-like superficial veins in mice. Subsequent experimental approaches revealed that interference with endothelial- and/or smooth muscle cell activation counteracts this remodeling process. Here, we investigate whether the herbal agent glycyrrhetinic acid (GA) is a suitable candidate for that purpose given its anti-proliferative as well as anti-oxidative properties. While basic abilities of cultured venous smooth muscle cells (SMCs) such as migration and proliferation were not influenced by GA, it inhibited proliferation but not angiogenic sprouting of human venous endothelial cells (ECs). Further analyses of biomechanically stimulated ECs revealed that GA inhibits the DNA binding capacity of the mechanosensitive transcription factor activator protein-1 (AP-1) which, however, had only a minor impact on the endothelial transcriptome. Nevertheless, by decreasing gelatinase activity in ECs or mouse veins exposed to biomechanical stress, GA diminished a crucial cellular response in the context of venous remodeling. In line with the observed inhibitory effects, local transdermal application of GA attenuated pressure-mediated enlargement of veins in the mouse auricle. In summary, our data identifies GA as an inhibitor of EC proliferation, gelatinase activity and venous remodeling. It may thus have the capacity to attenuate spider vein formation and remodeling in humans. 
650 4 |a Endothelial Cells 
650 4 |a Gelatinases 
650 4 |a Glycyrrhetinic Acid 
650 4 |a Pressure overload 
650 4 |a Smooth Muscle Cell 
650 4 |a Veins 
700 1 |a Arnold, Caroline  |e VerfasserIn  |0 (DE-588)1074276353  |0 (DE-627)831955406  |0 (DE-576)442346050  |4 aut 
700 1 |a Wagner, Andreas H.  |d 1963-  |e VerfasserIn  |0 (DE-588)1047559080  |0 (DE-627)778552381  |0 (DE-576)401158144  |4 aut 
700 1 |a Hecker, Markus  |d 1960-  |e VerfasserIn  |0 (DE-588)1071693344  |0 (DE-627)826266037  |0 (DE-576)433260319  |4 aut 
700 1 |a Sticht, Carsten  |d 1972-  |e VerfasserIn  |0 (DE-588)1020115718  |0 (DE-627)691110077  |0 (DE-576)250042177  |4 aut 
700 1 |a Korff, Thomas  |e VerfasserIn  |0 (DE-588)1048734951  |0 (DE-627)781211824  |0 (DE-576)386952604  |4 aut 
773 0 8 |i Enthalten in  |t Frontiers in physiology  |d Lausanne : Frontiers Research Foundation, 2007  |g 9(2018) Artikel-Nummer 320, 12 Seiten  |h Online-Ressource  |w (DE-627)631498788  |w (DE-600)2564217-0  |w (DE-576)32655095X  |x 1664-042X  |7 nnas  |a Glycyrrhetinic acid antagonizes pressure-induced venous remodeling in mice 
773 1 8 |g volume:9  |g year:2018  |a Glycyrrhetinic acid antagonizes pressure-induced venous remodeling in mice 
856 4 0 |u http://dx.doi.org/10.3389/fphys.2018.00320  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://www.frontiersin.org/articles/10.3389/fphys.2018.00320/full  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20180420 
993 |a Article 
994 |a 2018 
998 |g 1048734951  |a Korff, Thomas  |m 1048734951:Korff, Thomas  |d 50000  |d 53200  |e 50000PK1048734951  |e 53200PK1048734951  |k 0/50000/  |k 1/50000/53200/  |p 6  |y j 
998 |g 1020115718  |a Sticht, Carsten  |m 1020115718:Sticht, Carsten  |d 60000  |d 61400  |e 60000PS1020115718  |e 61400PS1020115718  |k 0/60000/  |k 1/60000/61400/  |p 5 
998 |g 1071693344  |a Hecker, Markus  |m 1071693344:Hecker, Markus  |d 50000  |d 53200  |e 50000PH1071693344  |e 53200PH1071693344  |k 0/50000/  |k 1/50000/53200/  |p 4 
998 |g 1047559080  |a Wagner, Andreas H.  |m 1047559080:Wagner, Andreas H.  |d 50000  |d 53200  |e 50000PW1047559080  |e 53200PW1047559080  |k 0/50000/  |k 1/50000/53200/  |p 3 
998 |g 1074276353  |a Arnold, Caroline  |m 1074276353:Arnold, Caroline  |d 50000  |d 53200  |e 50000PA1074276353  |e 53200PA1074276353  |k 0/50000/  |k 1/50000/53200/  |p 2 
998 |g 1150443944  |a Kuk, Hanna  |m 1150443944:Kuk, Hanna  |d 50000  |d 53200  |e 50000PK1150443944  |e 53200PK1150443944  |k 0/50000/  |k 1/50000/53200/  |p 1  |x j 
999 |a KXP-PPN1572219750  |e 3006541871 
BIB |a Y 
SER |a journal 
JSO |a {"note":["Gesehen am 20.04.2018"],"person":[{"display":"Kuk, Hanna","family":"Kuk","role":"aut","given":"Hanna"},{"display":"Arnold, Caroline","family":"Arnold","given":"Caroline","role":"aut"},{"role":"aut","given":"Andreas H.","family":"Wagner","display":"Wagner, Andreas H."},{"display":"Hecker, Markus","family":"Hecker","role":"aut","given":"Markus"},{"display":"Sticht, Carsten","given":"Carsten","role":"aut","family":"Sticht"},{"family":"Korff","role":"aut","given":"Thomas","display":"Korff, Thomas"}],"title":[{"title":"Glycyrrhetinic acid antagonizes pressure-induced venous remodeling in mice","title_sort":"Glycyrrhetinic acid antagonizes pressure-induced venous remodeling in mice"}],"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"04 April 2018"}],"id":{"doi":["10.3389/fphys.2018.00320"],"eki":["1572219750"]},"name":{"displayForm":["Hanna Kuk, Caroline Arnold, Andreas H. Wagner, Markus Hecker, Carsten Sticht and Thomas Korff"]},"language":["eng"],"recId":"1572219750","type":{"media":"Online-Ressource","bibl":"article-journal"},"relHost":[{"origin":[{"dateIssuedKey":"2007","publisherPlace":"Lausanne","publisher":"Frontiers Research Foundation","dateIssuedDisp":"2007-"}],"title":[{"title_sort":"Frontiers in physiology","title":"Frontiers in physiology"}],"note":["Gesehen am 24.05.23"],"disp":"Glycyrrhetinic acid antagonizes pressure-induced venous remodeling in miceFrontiers in physiology","type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1664-042X"],"eki":["631498788"],"zdb":["2564217-0"]},"part":{"year":"2018","text":"9(2018) Artikel-Nummer 320, 12 Seiten","volume":"9"},"pubHistory":["2007 -"],"recId":"631498788","name":{"displayForm":["Frontiers Research Foundation"]}}]} 
SRT |a KUKHANNAARGLYCYRRHET0420 

Similar Items