Drug repositioning meets precision in glioblastoma
Glioblastoma has a gigantic unmet medical need. Molecular knowledge has evolved substantially, including data on clonal selection with progression. Past trials for all-comers may have produced false negative results. Molecular precision at progression needs workup of new tissue, and revisiting drugs...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 2018
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| In: |
Clinical cancer research
Year: 2018, Volume: 24, Issue: 2, Pages: 256-258 |
| ISSN: | 1557-3265 |
| DOI: | 10.1158/1078-0432.CCR-17-2989 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1158/1078-0432.CCR-17-2989 Verlag, kostenfrei, Volltext: http://clincancerres.aacrjournals.org/content/24/2/256 
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| Author Notes: | Wolfgang Wick, Tobias Kessler |
| Summary: | Glioblastoma has a gigantic unmet medical need. Molecular knowledge has evolved substantially, including data on clonal selection with progression. Past trials for all-comers may have produced false negative results. Molecular precision at progression needs workup of new tissue, and revisiting drugs with a focus on brain tumor penetration may yield surprises. Clin Cancer Res; 24(2); 256-8. ©2017 AACR. See related article by Byron et al., p. 295 |
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| Item Description: | Gesehen am 23.04.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1557-3265 |
| DOI: | 10.1158/1078-0432.CCR-17-2989 |