Metronomic cyclophosphamide treatment in metastasized breast cancer patients: immunological effects and clinical outcome
Severe immune suppression is frequent in late-stage tumor patients and promotes tumor immune evasion and subsequent tumor progression. Regulatory T cells (Treg) are major suppressors of anti-tumor immune responses. Therefore, targeting of Treg has become a key goal of anti-tumor therapy. Several pre...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2012
|
| In: |
Cancer immunology immunotherapy
Year: 2011, Jahrgang: 61, Heft: 3, Pages: 353-362 |
| ISSN: | 1432-0851 |
| DOI: | 10.1007/s00262-011-1106-3 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1007/s00262-011-1106-3 Verlag, Volltext: https://link.springer.com/article/10.1007/s00262-011-1106-3 
|
| Verfasserangaben: | Yingzi Ge, Christoph Domschke, Natalija Stoiber, Sarah Schott, Joerg Heil, Joachim Rom, Maria Blumenstein, Janina Thum, Christof Sohn, Andreas Schneeweiss, Philipp Beckhove, Florian Schuetz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1572349778 | ||
| 003 | DE-627 | ||
| 005 | 20230426124259.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180425r20122011xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00262-011-1106-3 |2 doi | |
| 035 | |a (DE-627)1572349778 | ||
| 035 | |a (DE-576)502349778 | ||
| 035 | |a (DE-599)BSZ502349778 | ||
| 035 | |a (OCoLC)1341007735 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Ge, Yingzi |e VerfasserIn |0 (DE-588)138549923 |0 (DE-627)60380232X |0 (DE-576)308011171 |4 aut | |
| 245 | 1 | 0 | |a Metronomic cyclophosphamide treatment in metastasized breast cancer patients |b immunological effects and clinical outcome |c Yingzi Ge, Christoph Domschke, Natalija Stoiber, Sarah Schott, Joerg Heil, Joachim Rom, Maria Blumenstein, Janina Thum, Christof Sohn, Andreas Schneeweiss, Philipp Beckhove, Florian Schuetz |
| 264 | 1 | |c 2012 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online: 14 September 2011 | ||
| 500 | |a Gesehen am 25.04.2018 | ||
| 520 | |a Severe immune suppression is frequent in late-stage tumor patients and promotes tumor immune evasion and subsequent tumor progression. Regulatory T cells (Treg) are major suppressors of anti-tumor immune responses. Therefore, targeting of Treg has become a key goal of anti-tumor therapy. Several preclinical and clinical observations suggest that Treg can be depleted by cyclophosphamide. Over a period of 3 months, we investigated the effect of metronomic low-dose cyclophosphamide on Treg numbers, suppressive capacity and proliferation on endogenous anti-tumor T-cell responses and on their correlation to clinical outcome in 12 patients with treatment-refractory metastasized breast cancer who received single-agent 50 mg cyclophosphamide p.o. daily. Cyclophosphamide treatment initially caused a significant reduction in circulating Treg by more than 40% (P = 0.002). However, Treg numbers completely recovered during the treatment due to increased proliferative activity and maintained their suppressive capacity. Treg depletion coincided with a strong increase in breast tumor-reactive T cells (P = 0.03) that remained at high levels during the whole period. Numbers of tumor-reactive T cells but not of Treg correlated with disease stabilization (P = 0.03) and overall survival (P = 0.027). We conclude that metronomic low-dose cyclophosphamide only transiently reduces Treg but induces stable tumor-specific T-cell responses, which correlate with improved clinical outcome in advanced-stage breast cancer patients. | ||
| 534 | |c 2011 | ||
| 700 | 1 | |a Domschke, Christoph |d 1982- |e VerfasserIn |0 (DE-588)139103201 |0 (DE-627)703207679 |0 (DE-576)310245095 |4 aut | |
| 700 | 1 | |a Schott, Sarah |d 1981- |e VerfasserIn |0 (DE-588)133730816 |0 (DE-627)552697281 |0 (DE-576)27460678X |4 aut | |
| 700 | 1 | |a Heil, Jörg |d 1978- |e VerfasserIn |0 (DE-588)132580187 |0 (DE-627)52396160X |0 (DE-576)299238679 |4 aut | |
| 700 | 1 | |a Rom, Joachim |d 1975- |e VerfasserIn |0 (DE-588)130877018 |0 (DE-627)707590604 |0 (DE-576)298390833 |4 aut | |
| 700 | 1 | |a Blumenstein, Maria |d 1973- |e VerfasserIn |0 (DE-588)137640757 |0 (DE-627)594509084 |0 (DE-576)303750642 |4 aut | |
| 700 | 1 | |a Thum, Janina |d 1983- |e VerfasserIn |0 (DE-588)1052369685 |0 (DE-627)788453009 |0 (DE-576)408116625 |4 aut | |
| 700 | 1 | |a Sohn, Christof |d 1961- |e VerfasserIn |0 (DE-588)131349287 |0 (DE-627)507642902 |0 (DE-576)298422255 |4 aut | |
| 700 | 1 | |a Schneeweiss, Andreas |d 1961- |e VerfasserIn |0 (DE-588)109972554 |0 (DE-627)632849630 |0 (DE-576)327251859 |4 aut | |
| 700 | 1 | |a Beckhove, Philipp |d 1969- |e VerfasserIn |0 (DE-588)121272842 |0 (DE-627)705350169 |0 (DE-576)292620748 |4 aut | |
| 700 | 1 | |a Schütz, Florian |d 1972- |e VerfasserIn |0 (DE-588)12303387X |0 (DE-627)082307229 |0 (DE-576)293528810 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer immunology immunotherapy |d Berlin : Springer, 1976 |g 61(2012), 3, Seite 353-362 |h Online-Ressource |w (DE-627)253390443 |w (DE-600)1458489-X |w (DE-576)072283475 |x 1432-0851 |7 nnas |a Metronomic cyclophosphamide treatment in metastasized breast cancer patients immunological effects and clinical outcome |
| 773 | 1 | 8 | |g volume:61 |g year:2012 |g number:3 |g pages:353-362 |g extent:10 |a Metronomic cyclophosphamide treatment in metastasized breast cancer patients immunological effects and clinical outcome |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00262-011-1106-3 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://link.springer.com/article/10.1007/s00262-011-1106-3 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180425 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 12303387X |a Schütz, Florian |m 12303387X:Schütz, Florian |d 910000 |d 910400 |e 910000PS12303387X |e 910400PS12303387X |k 0/910000/ |k 1/910000/910400/ |p 12 |y j | ||
| 998 | |g 121272842 |a Beckhove, Philipp |m 121272842:Beckhove, Philipp |d 140000 |e 140000PB121272842 |k 0/140000/ |p 11 | ||
| 998 | |g 109972554 |a Schneeweiss, Andreas |m 109972554:Schneeweiss, Andreas |d 910000 |d 910400 |e 910000PS109972554 |e 910400PS109972554 |k 0/910000/ |k 1/910000/910400/ |p 10 | ||
| 998 | |g 131349287 |a Sohn, Christof |m 131349287:Sohn, Christof |d 910000 |d 910400 |e 910000PS131349287 |e 910400PS131349287 |k 0/910000/ |k 1/910000/910400/ |p 9 | ||
| 998 | |g 1052369685 |a Thum, Janina |m 1052369685:Thum, Janina |d 910000 |d 910400 |e 910000PT1052369685 |e 910400PT1052369685 |k 0/910000/ |k 1/910000/910400/ |p 8 | ||
| 998 | |g 137640757 |a Blumenstein, Maria |m 137640757:Blumenstein, Maria |d 910000 |d 910400 |e 910000PB137640757 |e 910400PB137640757 |k 0/910000/ |k 1/910000/910400/ |p 7 | ||
| 998 | |g 130877018 |a Rom, Joachim |m 130877018:Rom, Joachim |d 910000 |d 910400 |e 910000PR130877018 |e 910400PR130877018 |k 0/910000/ |k 1/910000/910400/ |p 6 | ||
| 998 | |g 132580187 |a Heil, Jörg |m 132580187:Heil, Jörg |d 910000 |d 910400 |e 910000PH132580187 |e 910400PH132580187 |k 0/910000/ |k 1/910000/910400/ |p 5 | ||
| 998 | |g 133730816 |a Schott, Sarah |m 133730816:Schott, Sarah |d 910000 |d 910400 |e 910000PS133730816 |e 910400PS133730816 |k 0/910000/ |k 1/910000/910400/ |p 4 | ||
| 998 | |g 139103201 |a Domschke, Christoph |m 139103201:Domschke, Christoph |d 910000 |d 910400 |e 910000PD139103201 |e 910400PD139103201 |k 0/910000/ |k 1/910000/910400/ |p 2 | ||
| 998 | |g 138549923 |a Ge, Yingzi |m 138549923:Ge, Yingzi |d 910000 |e 910000PG138549923 |k 0/910000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1572349778 |e 3007043247 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Ge","display":"Ge, Yingzi","given":"Yingzi","role":"aut"},{"display":"Domschke, Christoph","family":"Domschke","given":"Christoph","role":"aut"},{"given":"Sarah","role":"aut","display":"Schott, Sarah","family":"Schott"},{"given":"Jörg","role":"aut","display":"Heil, Jörg","family":"Heil"},{"given":"Joachim","role":"aut","family":"Rom","display":"Rom, Joachim"},{"display":"Blumenstein, Maria","family":"Blumenstein","role":"aut","given":"Maria"},{"role":"aut","given":"Janina","display":"Thum, Janina","family":"Thum"},{"family":"Sohn","display":"Sohn, Christof","given":"Christof","role":"aut"},{"role":"aut","given":"Andreas","family":"Schneeweiss","display":"Schneeweiss, Andreas"},{"given":"Philipp","role":"aut","family":"Beckhove","display":"Beckhove, Philipp"},{"family":"Schütz","display":"Schütz, Florian","role":"aut","given":"Florian"}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title_sort":"Metronomic cyclophosphamide treatment in metastasized breast cancer patients","subtitle":"immunological effects and clinical outcome","title":"Metronomic cyclophosphamide treatment in metastasized breast cancer patients"}],"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"2012"}],"note":["Published online: 14 September 2011","Gesehen am 25.04.2018"],"id":{"eki":["1572349778"],"doi":["10.1007/s00262-011-1106-3"]},"recId":"1572349778","relHost":[{"id":{"eki":["253390443"],"issn":["1432-0851"],"zdb":["1458489-X"]},"physDesc":[{"extent":"Online-Ressource"}],"recId":"253390443","disp":"Metronomic cyclophosphamide treatment in metastasized breast cancer patients immunological effects and clinical outcomeCancer immunology immunotherapy","type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title_sort":"Cancer immunology immunotherapy","subtitle":"CII","title":"Cancer immunology immunotherapy"}],"pubHistory":["1.1976 -"],"note":["Gesehen am 15.05.2024","Fortsetzung der Druck-Ausgabe","Ungezählte Beil. ab 52.2003: Supplement"],"origin":[{"dateIssuedDisp":"1976-","publisher":"Springer","dateIssuedKey":"1976","publisherPlace":"Berlin ; Heidelberg"}],"titleAlt":[{"title":"CII"}],"part":{"volume":"61","extent":"10","pages":"353-362","year":"2012","issue":"3","text":"61(2012), 3, Seite 353-362"},"language":["eng"]}],"physDesc":[{"extent":"10 S."}],"name":{"displayForm":["Yingzi Ge, Christoph Domschke, Natalija Stoiber, Sarah Schott, Joerg Heil, Joachim Rom, Maria Blumenstein, Janina Thum, Christof Sohn, Andreas Schneeweiss, Philipp Beckhove, Florian Schuetz"]}} | ||
| SRT | |a GEYINGZIDOMETRONOMIC2012 | ||