A phase II study for metabolic in vivo response monitoring with sequential 18FDG-PET-CT during treatment with the EGFR-monoclonal-antibody cetuximab in metastatic colorectal cancer: the Heidelberg REMOTUX trial
The epidermal growth factor receptor monoclonal antibody cetuximab has proven activity in metastatic colorectal cancer. To date, the mechanisms of action are not completely understood. Especially the impact on tumor glucose metabolism, or tumor vascularization remains largely unclear. The understand...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
22 March 2012
|
| In: |
BMC cancer
Year: 2012, Jahrgang: 12, Pages: 1-6 |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/1471-2407-12-108 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/1471-2407-12-108 Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1471-2407-12-108 
|
| Verfasserangaben: | Anne Katrin Berger, Carl von Gall, Ulrich Abel, Stefan Delorme, Matthias Kloor, Jennifer Ose, Tim Frederik Weber, Annika Stange, Georg Martin Haag, Uwe Haberkorn, Florian Lordick and Dirk Jäger |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1572358572 | ||
| 003 | DE-627 | ||
| 005 | 20241029104402.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180425s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/1471-2407-12-108 |2 doi | |
| 035 | |a (DE-627)1572358572 | ||
| 035 | |a (DE-576)502358572 | ||
| 035 | |a (DE-599)BSZ502358572 | ||
| 035 | |a (OCoLC)1341007762 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Berger, Anne Katrin |d 1978- |e VerfasserIn |0 (DE-588)132177889 |0 (DE-627)519022424 |0 (DE-576)298988380 |4 aut | |
| 245 | 1 | 2 | |a A phase II study for metabolic in vivo response monitoring with sequential 18FDG-PET-CT during treatment with the EGFR-monoclonal-antibody cetuximab in metastatic colorectal cancer |b the Heidelberg REMOTUX trial |c Anne Katrin Berger, Carl von Gall, Ulrich Abel, Stefan Delorme, Matthias Kloor, Jennifer Ose, Tim Frederik Weber, Annika Stange, Georg Martin Haag, Uwe Haberkorn, Florian Lordick and Dirk Jäger |
| 246 | 3 | 3 | |a A phase II study for metabolic in vivo response monitoring with sequential 18 FDG-PET-CT during treatment with the EGFR-monoclonal-antibody cetuximab in metastatic colorectal cancer |
| 264 | 1 | |c 22 March 2012 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.10.2024 | ||
| 500 | |a Im Titel ist "18" hochgestellt | ||
| 520 | |a The epidermal growth factor receptor monoclonal antibody cetuximab has proven activity in metastatic colorectal cancer. To date, the mechanisms of action are not completely understood. Especially the impact on tumor glucose metabolism, or tumor vascularization remains largely unclear. The understanding of mechanisms such as early changes in tumor metabolism is of clinical importance since there may be a substantial influence on choice and sequence of drug combinations. Early signals of response to cetuximab may prove useful to identify patients having a relevant clinical treatment benefit. The objective of this trial is to evaluate the predictive relevance of the relative change in 18 F-Fluorodeoxyglucose tumor uptake for early clinical response during short-term single agent treatment with cetuximab. Early clinical response will be routinely measured according to the response evaluation criteria in solid tumors. Accompanying research includes cytokine immune monitoring and analysis of tumor proteins and tumor genes. | ||
| 650 | 4 | |a 18F-FDG PET CT | |
| 650 | 4 | |a Cetuximab | |
| 650 | 4 | |a Colorectal cancer | |
| 650 | 4 | |a Metabolic imaging | |
| 650 | 4 | |a Metastases | |
| 700 | 1 | |a Abel, Ulrich |d 1952- |e VerfasserIn |0 (DE-588)14287552X |0 (DE-627)640555403 |0 (DE-576)333774582 |4 aut | |
| 700 | 1 | |a Kloor, Matthias |d 1972- |e VerfasserIn |0 (DE-588)124552803 |0 (DE-627)363416609 |0 (DE-576)294228616 |4 aut | |
| 700 | 1 | |a Ose, Jennifer |d 1979- |e VerfasserIn |0 (DE-588)1136678018 |0 (DE-627)893435805 |0 (DE-576)490759270 |4 aut | |
| 700 | 1 | |a Weber, Tim |d 1977- |e VerfasserIn |0 (DE-588)133392694 |0 (DE-627)544045017 |0 (DE-576)299816613 |4 aut | |
| 700 | 1 | |a Stange, Annika |e VerfasserIn |0 (DE-588)1137859814 |0 (DE-627)895137607 |0 (DE-576)49178001X |4 aut | |
| 700 | 1 | |a Haag, Georg Martin |d 1979- |e VerfasserIn |0 (DE-588)133390934 |0 (DE-627)544043863 |0 (DE-576)29981548X |4 aut | |
| 700 | 1 | |a Haberkorn, Uwe |d 1959- |e VerfasserIn |0 (DE-588)1022913905 |0 (DE-627)717331245 |0 (DE-576)366166352 |4 aut | |
| 700 | 1 | |a Jäger, Dirk |d 1964- |e VerfasserIn |0 (DE-588)1032507535 |0 (DE-627)738505323 |0 (DE-576)380074125 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t BMC cancer |d London : BioMed Central, 2001 |g 12(2012), Artikel-ID 108, Seite 1-6 |h Online-Ressource |w (DE-627)326643710 |w (DE-600)2041352-X |w (DE-576)107014645 |x 1471-2407 |7 nnas |a A phase II study for metabolic in vivo response monitoring with sequential 18FDG-PET-CT during treatment with the EGFR-monoclonal-antibody cetuximab in metastatic colorectal cancer the Heidelberg REMOTUX trial |
| 773 | 1 | 8 | |g volume:12 |g year:2012 |g elocationid:108 |g pages:1-6 |g extent:6 |a A phase II study for metabolic in vivo response monitoring with sequential 18FDG-PET-CT during treatment with the EGFR-monoclonal-antibody cetuximab in metastatic colorectal cancer the Heidelberg REMOTUX trial |
| 856 | 4 | 0 | |u https://doi.org/10.1186/1471-2407-12-108 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1186/1471-2407-12-108 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180425 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 1032507535 |a Jäger, Dirk |m 1032507535:Jäger, Dirk |d 910000 |e 910000PJ1032507535 |k 0/910000/ |p 12 |y j | ||
| 998 | |g 1022913905 |a Haberkorn, Uwe |m 1022913905:Haberkorn, Uwe |d 910000 |d 911400 |e 910000PH1022913905 |e 911400PH1022913905 |k 0/910000/ |k 1/910000/911400/ |p 10 | ||
| 998 | |g 133390934 |a Haag, Georg Martin |m 133390934:Haag, Georg Martin |d 910000 |e 910000PH133390934 |k 0/910000/ |p 9 | ||
| 998 | |g 1137859814 |a Stange, Annika |m 1137859814:Stange, Annika |d 910000 |e 910000PS1137859814 |k 0/910000/ |p 8 | ||
| 998 | |g 133392694 |a Weber, Tim |m 133392694:Weber, Tim |d 910000 |d 911400 |e 910000PW133392694 |e 911400PW133392694 |k 0/910000/ |k 1/910000/911400/ |p 7 | ||
| 998 | |g 1136678018 |a Ose, Jennifer |m 1136678018:Ose, Jennifer |d 50000 |e 50000PO1136678018 |k 0/50000/ |p 6 | ||
| 998 | |g 124552803 |a Kloor, Matthias |m 124552803:Kloor, Matthias |d 910000 |d 912000 |e 910000PK124552803 |e 912000PK124552803 |k 0/910000/ |k 1/910000/912000/ |p 5 | ||
| 998 | |g 14287552X |a Abel, Ulrich |m 14287552X:Abel, Ulrich |d 50000 |d 910000 |d 999701 |e 50000PA14287552X |e 910000PA14287552X |e 999701PA14287552X |k 0/50000/ |k 0/910000/ |k 1/910000/999701/ |p 3 | ||
| 998 | |g 132177889 |a Berger, Anne Katrin |m 132177889:Berger, Anne Katrin |d 910000 |e 910000PB132177889 |k 0/910000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1572358572 |e 3007057574 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1572358572","origin":[{"dateIssuedDisp":"22 March 2012","dateIssuedKey":"2012"}],"name":{"displayForm":["Anne Katrin Berger, Carl von Gall, Ulrich Abel, Stefan Delorme, Matthias Kloor, Jennifer Ose, Tim Frederik Weber, Annika Stange, Georg Martin Haag, Uwe Haberkorn, Florian Lordick and Dirk Jäger"]},"person":[{"role":"aut","display":"Berger, Anne Katrin","given":"Anne Katrin","family":"Berger"},{"role":"aut","display":"Abel, Ulrich","given":"Ulrich","family":"Abel"},{"role":"aut","family":"Kloor","display":"Kloor, Matthias","given":"Matthias"},{"family":"Ose","given":"Jennifer","display":"Ose, Jennifer","role":"aut"},{"given":"Tim","display":"Weber, Tim","family":"Weber","role":"aut"},{"role":"aut","display":"Stange, Annika","given":"Annika","family":"Stange"},{"given":"Georg Martin","display":"Haag, Georg Martin","family":"Haag","role":"aut"},{"family":"Haberkorn","display":"Haberkorn, Uwe","given":"Uwe","role":"aut"},{"role":"aut","given":"Dirk","display":"Jäger, Dirk","family":"Jäger"}],"titleAlt":[{"title":"A phase II study for metabolic in vivo response monitoring with sequential 18 FDG-PET-CT during treatment with the EGFR-monoclonal-antibody cetuximab in metastatic colorectal cancer"}],"language":["eng"],"title":[{"title":"A phase II study for metabolic in vivo response monitoring with sequential 18FDG-PET-CT during treatment with the EGFR-monoclonal-antibody cetuximab in metastatic colorectal cancer","title_sort":"phase II study for metabolic in vivo response monitoring with sequential 18FDG-PET-CT during treatment with the EGFR-monoclonal-antibody cetuximab in metastatic colorectal cancer","subtitle":"the Heidelberg REMOTUX trial"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1186/1471-2407-12-108"],"eki":["1572358572"]},"physDesc":[{"extent":"6 S."}],"relHost":[{"origin":[{"dateIssuedKey":"2001","publisherPlace":"London ; Berlin ; Heidelberg","publisher":"BioMed Central ; Springer","dateIssuedDisp":"2001-"}],"title":[{"title":"BMC cancer","title_sort":"BMC cancer"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["326643710"],"zdb":["2041352-X"],"issn":["1471-2407"]},"part":{"text":"12(2012), Artikel-ID 108, Seite 1-6","volume":"12","year":"2012","extent":"6","pages":"1-6"},"note":["Gesehen am 22.05.20"],"recId":"326643710","disp":"A phase II study for metabolic in vivo response monitoring with sequential 18FDG-PET-CT during treatment with the EGFR-monoclonal-antibody cetuximab in metastatic colorectal cancer the Heidelberg REMOTUX trialBMC cancer","language":["eng"],"pubHistory":["1.2001 -"],"type":{"media":"Online-Ressource","bibl":"periodical"}}],"note":["Gesehen am 29.10.2024","Im Titel ist \"18\" hochgestellt"]} | ||
| SRT | |a BERGERANNEPHASEIISTU2220 | ||