Spatially resolved monitoring of neutrophil elastase activity with tatiometric fluorescent reporters
Finding NEmo: In a mouse model for lung inflammation, the lipidated peptide-based ratiometric fluorescent reporter NEmo-2 indicates that neutrophil elastase (NE) activity is mainly associated with the surface of neutrophils (see scheme), whereas a soluble reporter variant showed no activity in the l...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 May 2012
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| In: |
Angewandte Chemie. International edition
Year: 2012, Jahrgang: 51, Heft: 25, Pages: 6258-6261 |
| ISSN: | 1521-3773 |
| DOI: | 10.1002/anie.201109226 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1002/anie.201109226 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201109226 
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| Verfasserangaben: | Stefanie Gehrig, Marcus A. Mall, and Carsten Schultz |
| Zusammenfassung: | Finding NEmo: In a mouse model for lung inflammation, the lipidated peptide-based ratiometric fluorescent reporter NEmo-2 indicates that neutrophil elastase (NE) activity is mainly associated with the surface of neutrophils (see scheme), whereas a soluble reporter variant showed no activity in the lung fluid, likely because of the abundance of antiproteases. Targeting the localization of NE activity has great potential for the development of improved antiinflammatory drugs. |
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| Beschreibung: | Gesehen am 25.04.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1521-3773 |
| DOI: | 10.1002/anie.201109226 |