Strategies preventing contrast-induced nephropathy after coronary angiography: a comprehensive meta-analysis and systematic review of 125 randomized controlled trials
This systematic review with meta-analysis sought to determine the strength of evidence for the effects of hydration (sodium bicarbonate [SB] and normal saline [NS]), supplementations ( N-acetylcysteine [NAC] and vitamin C), and some common drugs (adenosine antagonists [AAs], statins, loop diuretics,...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017
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| In: |
Angiology
Year: 2017, Volume: 68, Issue: 5, Pages: 389-413 |
| ISSN: | 1940-1574 |
| DOI: | 10.1177/0003319716661445 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1177/0003319716661445
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| Author Notes: | Sadeq Ali-Hasan-Al-Saegh, Seyed Jalil Mirhosseini, Zahra Ghodratipour, Zahra Sarrafan-Chaharsoughi, Elham Rahimizadeh, Ali Akbar Karimi-Bondarabadi, Fatemeh Haddad, Arezoo Shahidzadeh, Parisa Mahdavi, Ali-Mohammad Dehghan, Mahbube Tahernejad, Azadeh Shahidzadeh, Hamidreza Dehghan, Azam Ghanei, Mohammadreza Lotfaliani, Alexander Weymann, Mohamed Zeriouh, Aron-Frederik Popov, Anton Sabashnikov |
| Summary: | This systematic review with meta-analysis sought to determine the strength of evidence for the effects of hydration (sodium bicarbonate [SB] and normal saline [NS]), supplementations ( N-acetylcysteine [NAC] and vitamin C), and some common drugs (adenosine antagonists [AAs], statins, loop diuretics, and angiotensin-converting enzyme inhibitors [ACEIs]) on the incidence of contrast-induced nephropathy (CIN) and requirement for hemodialysis after coronary angiography. After screening, a total of 125 trials that reported outcomes were identified. Pooled analysis indicated beneficial effects of SB versus NS (odds ratio [OR] = 0.73; 95% confidence interval [CI]: 0.56-0.94; P = .01), NAC (OR = 0.79; 95% CI: 0.70-0.88; P = .001), vitamin C (OR = 0.64; 95% CI: 0.45-0.89; P = .01), statins (OR = 0.45; 95% CI: 0.35-0.57; P = .001), AA (OR = 0.28; 95% CI: 0.14-0.47; P = .001), loop diuretics (OR = 0.97; 95% CI: 0.33-2.85; P = .9), and ACEI (OR = 1.06; 95% CI: 0.69-1.61; P = .8). Overall, hydration with SB, use of supplements, such as NAC and vitamin C, and administration of statins and AA should always be considered for the prevention of CIN after coronary angiography. |
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| Item Description: | Published online: August 1, 2016 Gesehen am 25.04.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1940-1574 |
| DOI: | 10.1177/0003319716661445 |