Microglia activation and schizophrenia: lessons from the effects of minocycline on postnatal neurogenesis, neuronal survival and synaptic pruning
The implication of neuroinflammation in schizophrenia, sustained by recent genetic evidence, represents one of the most exciting topics in schizophrenia research. Drugs which inhibit microglia activation, especially the classical tetracycline antibiotic minocycline are currently under investigation...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 May 2017
|
| In: |
Schizophrenia bulletin
Year: 2017, Jahrgang: 43, Heft: 3, Pages: 493-496 |
| ISSN: | 1745-1701 |
| DOI: | 10.1093/schbul/sbw088 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1093/schbul/sbw088 Verlag, Volltext: https://academic.oup.com/schizophreniabulletin/article/43/3/493/2503484 
|
| Verfasserangaben: | Dragos Inta, Undine E. Lang, Stefan Borgwardt, Andreas Meyer-Lindenberg, and Peter Gass |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 157237246X | ||
| 003 | DE-627 | ||
| 005 | 20230426124302.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180425s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/schbul/sbw088 |2 doi | |
| 035 | |a (DE-627)157237246X | ||
| 035 | |a (DE-576)50237246X | ||
| 035 | |a (DE-599)BSZ50237246X | ||
| 035 | |a (OCoLC)1341007804 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Inta, Dragos |d 1972- |e VerfasserIn |0 (DE-588)133064980 |0 (DE-627)533317088 |0 (DE-576)299599701 |4 aut | |
| 245 | 1 | 0 | |a Microglia activation and schizophrenia |b lessons from the effects of minocycline on postnatal neurogenesis, neuronal survival and synaptic pruning |c Dragos Inta, Undine E. Lang, Stefan Borgwardt, Andreas Meyer-Lindenberg, and Peter Gass |
| 264 | 1 | |c 1 May 2017 | |
| 300 | |a 4 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.04.2018 | ||
| 520 | |a The implication of neuroinflammation in schizophrenia, sustained by recent genetic evidence, represents one of the most exciting topics in schizophrenia research. Drugs which inhibit microglia activation, especially the classical tetracycline antibiotic minocycline are currently under investigation as alternative antipsychotics. However, recent studies demonstrated that microglia activation is not only a hallmark of neuroinflammation, but plays important roles during brain development. Inhibition of microglia activation by minocycline was shown to induce extensive neuronal cell death and to impair subventricular zone (SVZ) neurogenesis and synaptic pruning in the early postnatal and adolescent rodent brain, respectively. These deleterious effects contrast with the neuroprotective actions of minocycline at adult stages. They are of potential importance for schizophrenia, since minocycline triggers similar pro-apoptotic effects in the developing brain as NMDA receptor (NMDAR) antagonists, known to induce long-term schizophrenia-like abnormalities. Moreover, altered postnatal neurogenesis, recently described in the human striatum, was proposed to induce striatal dopamine dysregulation associated with schizophrenia. Finally, the effect of minocycline on synapse remodeling is of interest considering the recently reported strong genetic association of the pruning-regulating complement factor gene C4A with schizophrenia. This raises the exciting possibility that in conditions of hyperactive synaptic pruning, as supposed in schizophrenia, the inhibitory action of minocycline turns into a beneficial effect, with relevance for early therapeutic interventions. Altogether, these data support a differential view on microglia activation and its inhibition. Further studies are needed to clarify the relevance of these results for the pathogenesis of schizophrenia and the use of minocycline as antipsychotic drug. | ||
| 700 | 1 | |a Meyer-Lindenberg, Andreas |d 1965- |e VerfasserIn |0 (DE-588)1029137390 |0 (DE-627)732483069 |0 (DE-576)376589876 |4 aut | |
| 700 | 1 | |a Gass, Peter |d 1963- |e VerfasserIn |0 (DE-588)13015945X |0 (DE-627)492009694 |0 (DE-576)298033771 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Schizophrenia bulletin |d Oxford : Oxford Univ. Press, 1969 |g 43(2017), 3, Seite 493-496 |h Online-Ressource |w (DE-627)481280243 |w (DE-600)2180196-4 |w (DE-576)261040812 |x 1745-1701 |7 nnas |a Microglia activation and schizophrenia lessons from the effects of minocycline on postnatal neurogenesis, neuronal survival and synaptic pruning |
| 773 | 1 | 8 | |g volume:43 |g year:2017 |g number:3 |g pages:493-496 |g extent:4 |a Microglia activation and schizophrenia lessons from the effects of minocycline on postnatal neurogenesis, neuronal survival and synaptic pruning |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/schbul/sbw088 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://academic.oup.com/schizophreniabulletin/article/43/3/493/2503484 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180425 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 13015945X |a Gass, Peter |m 13015945X:Gass, Peter |d 60000 |e 60000PG13015945X |k 0/60000/ |p 5 |y j | ||
| 998 | |g 1029137390 |a Meyer-Lindenberg, Andreas |m 1029137390:Meyer-Lindenberg, Andreas |d 60000 |d 700000 |d 718000 |e 60000PM1029137390 |e 700000PM1029137390 |e 718000PM1029137390 |k 0/60000/ |k 0/700000/ |k 1/700000/718000/ |p 4 | ||
| 998 | |g 133064980 |a Inta, Dragos |m 133064980:Inta, Dragos |d 60000 |e 60000PI133064980 |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN157237246X |e 3007077494 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1093/schbul/sbw088"],"eki":["157237246X"]},"name":{"displayForm":["Dragos Inta, Undine E. Lang, Stefan Borgwardt, Andreas Meyer-Lindenberg, and Peter Gass"]},"note":["Gesehen am 25.04.2018"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"title":[{"title_sort":"Microglia activation and schizophrenia","title":"Microglia activation and schizophrenia","subtitle":"lessons from the effects of minocycline on postnatal neurogenesis, neuronal survival and synaptic pruning"}],"relHost":[{"id":{"zdb":["2180196-4"],"eki":["481280243"],"issn":["1745-1701"]},"part":{"issue":"3","extent":"4","text":"43(2017), 3, Seite 493-496","pages":"493-496","volume":"43","year":"2017"},"name":{"displayForm":["US Department of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute of Mental Health"]},"pubHistory":["1.1969 -"],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 09.01.14"],"title":[{"title":"Schizophrenia bulletin","title_sort":"Schizophrenia bulletin"}],"origin":[{"publisher":"Oxford Univ. Press","publisherPlace":"Oxford","dateIssuedKey":"1969","dateIssuedDisp":"1969-"}],"disp":"Microglia activation and schizophrenia lessons from the effects of minocycline on postnatal neurogenesis, neuronal survival and synaptic pruningSchizophrenia bulletin","physDesc":[{"extent":"Online-Ressource"}],"recId":"481280243"}],"person":[{"display":"Inta, Dragos","family":"Inta","role":"aut","given":"Dragos"},{"given":"Andreas","role":"aut","family":"Meyer-Lindenberg","display":"Meyer-Lindenberg, Andreas"},{"family":"Gass","role":"aut","given":"Peter","display":"Gass, Peter"}],"origin":[{"dateIssuedDisp":"1 May 2017","dateIssuedKey":"2017"}],"physDesc":[{"extent":"4 S."}],"recId":"157237246X"} | ||
| SRT | |a INTADRAGOSMICROGLIAA1201 | ||