K27M-mutant histone-3 as a novel target for glioma immunotherapy
Mutation-specific vaccines have become increasingly important in glioma immunotherapy; however, shared neoepitopes are rare. For diffuse gliomas, a driver mutation in the gene for isocitrate dehydrogenase type-1 has been shown to produce an immunogenic epitope currently targeted in clinical trials....
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
05 Jul 2017
|
| In: |
OncoImmunology
Year: 2017, Jahrgang: 6, Heft: 7 |
| ISSN: | 2162-402X |
| DOI: | 10.1080/2162402X.2017.1328340 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1080/2162402X.2017.1328340 Verlag, Volltext: https://doi.org/10.1080/2162402X.2017.1328340 
|
| Verfasserangaben: | Katharina Ochs, Martina Ott, Theresa Bunse, Felix Sahm, Lukas Bunse, Katrin Deumelandt, Jana K. Sonner, Melanie Keil, Andreas von Deimling, Wolfgang Wick, Michael Platten |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1572373261 | ||
| 003 | DE-627 | ||
| 005 | 20220814123614.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180425s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/2162402X.2017.1328340 |2 doi | |
| 035 | |a (DE-627)1572373261 | ||
| 035 | |a (DE-576)502373261 | ||
| 035 | |a (DE-599)BSZ502373261 | ||
| 035 | |a (OCoLC)1341007616 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Sahm, Katharina |d 1985- |e VerfasserIn |0 (DE-588)1048541762 |0 (DE-627)780594371 |0 (DE-576)402374452 |4 aut | |
| 245 | 1 | 0 | |a K27M-mutant histone-3 as a novel target for glioma immunotherapy |c Katharina Ochs, Martina Ott, Theresa Bunse, Felix Sahm, Lukas Bunse, Katrin Deumelandt, Jana K. Sonner, Melanie Keil, Andreas von Deimling, Wolfgang Wick, Michael Platten |
| 264 | 1 | |c 05 Jul 2017 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.04.2018 | ||
| 520 | |a Mutation-specific vaccines have become increasingly important in glioma immunotherapy; however, shared neoepitopes are rare. For diffuse gliomas, a driver mutation in the gene for isocitrate dehydrogenase type-1 has been shown to produce an immunogenic epitope currently targeted in clinical trials. For highly aggressive midline gliomas, a recurrent point mutation in the histone-3 gene (H3F3A) causes an amino acid change from lysine to methionine at position 27 (K27M). Here, we demonstrate that a peptide vaccine against K27M-mutant histone-3 is capable of inducing effective, mutation-specific, cytotoxic T-cell- and T-helper-1-cell-mediated immune responses in a major histocompatibility complex (MHC)-humanized mouse model. By proving an immunologically effective presentation of the driver mutation H3K27M on MHC class II in human H3K27M-mutant gliomas, our data provide a basis for the further clinical development of vaccine-based or cell-based immunotherapeutic approaches targeting H3K27M. | ||
| 650 | 4 | |a Glioma | |
| 650 | 4 | |a K27M-mutant histone H3 | |
| 650 | 4 | |a neoepitope | |
| 650 | 4 | |a vaccination | |
| 700 | 1 | |a Ott, Martina |e VerfasserIn |0 (DE-588)1044429003 |0 (DE-627)772033285 |0 (DE-576)397204574 |4 aut | |
| 700 | 1 | |a Bunse, Theresa |d 1985- |e VerfasserIn |0 (DE-588)105282112X |0 (DE-627)789079070 |0 (DE-576)408553731 |4 aut | |
| 700 | 1 | |a Sahm, Felix |d 1984- |e VerfasserIn |0 (DE-588)1022852132 |0 (DE-627)717318478 |0 (DE-576)366075020 |4 aut | |
| 700 | 1 | |a Bunse, Lukas |d 1988- |e VerfasserIn |0 (DE-588)1051941229 |0 (DE-627)787187399 |0 (DE-576)407600426 |4 aut | |
| 700 | 1 | |a Deumelandt, Katrin |d 1989- |e VerfasserIn |0 (DE-588)1156686326 |0 (DE-627)1019521635 |0 (DE-576)502372974 |4 aut | |
| 700 | 1 | |a Sonner, Jana K. |e VerfasserIn |0 (DE-588)1082450510 |0 (DE-627)847510700 |0 (DE-576)455440778 |4 aut | |
| 700 | 1 | |a Keil, Melanie |e VerfasserIn |0 (DE-588)1054198128 |0 (DE-627)791227529 |0 (DE-576)410077402 |4 aut | |
| 700 | 1 | |a Deimling, Andreas von |d 1959- |e VerfasserIn |0 (DE-588)103034115X |0 (DE-627)735093946 |0 (DE-576)378138065 |4 aut | |
| 700 | 1 | |a Wick, Wolfgang |d 1970- |e VerfasserIn |0 (DE-588)120297736 |0 (DE-627)080586929 |0 (DE-576)186221320 |4 aut | |
| 700 | 1 | |a Platten, Michael |d 1971- |e VerfasserIn |0 (DE-588)121627780 |0 (DE-627)081431848 |0 (DE-576)261969811 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t OncoImmunology |d Abingdon : Taylor & Franics, 2012 |g 6(2017) Artikel-Nummer e1328340, 7 Seiten |h Online-Ressource |w (DE-627)683365428 |w (DE-600)2645309-5 |w (DE-576)356728366 |x 2162-402X |7 nnas |a K27M-mutant histone-3 as a novel target for glioma immunotherapy |
| 773 | 1 | 8 | |g volume:6 |g year:2017 |g number:7 |g extent:7 |a K27M-mutant histone-3 as a novel target for glioma immunotherapy |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/2162402X.2017.1328340 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.1080/2162402X.2017.1328340 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180425 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 121627780 |a Platten, Michael |m 121627780:Platten, Michael |d 60000 |d 62700 |e 60000PP121627780 |e 62700PP121627780 |k 0/60000/ |k 1/60000/62700/ |p 11 |y j | ||
| 998 | |g 120297736 |a Wick, Wolfgang |m 120297736:Wick, Wolfgang |d 910000 |d 911100 |e 910000PW120297736 |e 911100PW120297736 |k 0/910000/ |k 1/910000/911100/ |p 10 | ||
| 998 | |g 103034115X |a Deimling, Andreas von |m 103034115X:Deimling, Andreas von |d 910000 |d 912000 |e 910000PD103034115X |e 912000PD103034115X |k 0/910000/ |k 1/910000/912000/ |p 9 | ||
| 998 | |g 1054198128 |a Keil, Melanie |m 1054198128:Keil, Melanie |d 910000 |d 911100 |e 910000PK1054198128 |e 911100PK1054198128 |k 0/910000/ |k 1/910000/911100/ |p 8 | ||
| 998 | |g 1082450510 |a Sonner, Jana |m 1082450510:Sonner, Jana |d 910000 |d 911100 |e 910000PS1082450510 |e 911100PS1082450510 |k 0/910000/ |k 1/910000/911100/ |p 7 | ||
| 998 | |g 1156686326 |a Deumelandt, Katrin |m 1156686326:Deumelandt, Katrin |d 60000 |d 62700 |e 60000PD1156686326 |e 62700PD1156686326 |k 0/60000/ |k 1/60000/62700/ |p 6 | ||
| 998 | |g 1051941229 |a Bunse, Lukas |m 1051941229:Bunse, Lukas |d 910000 |d 911100 |e 910000PB1051941229 |e 911100PB1051941229 |k 0/910000/ |k 1/910000/911100/ |p 5 | ||
| 998 | |g 1022852132 |a Sahm, Felix |m 1022852132:Sahm, Felix |d 910000 |d 912000 |e 910000PS1022852132 |e 912000PS1022852132 |k 0/910000/ |k 1/910000/912000/ |p 4 | ||
| 998 | |g 105282112X |a Bunse, Theresa |m 105282112X:Bunse, Theresa |d 60000 |d 62700 |e 60000PB105282112X |e 62700PB105282112X |k 0/60000/ |k 1/60000/62700/ |p 3 | ||
| 998 | |g 1044429003 |a Ott, Martina |m 1044429003:Ott, Martina |d 910000 |d 911100 |e 910000PO1044429003 |e 911100PO1044429003 |k 0/910000/ |k 1/910000/911100/ |p 2 | ||
| 998 | |g 1048541762 |a Sahm, Katharina |m 1048541762:Sahm, Katharina |d 910000 |d 911100 |e 910000PS1048541762 |e 911100PS1048541762 |k 0/910000/ |k 1/910000/911100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1572373261 |e 3007078431 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1572373261","id":{"eki":["1572373261"],"doi":["10.1080/2162402X.2017.1328340"]},"name":{"displayForm":["Katharina Ochs, Martina Ott, Theresa Bunse, Felix Sahm, Lukas Bunse, Katrin Deumelandt, Jana K. Sonner, Melanie Keil, Andreas von Deimling, Wolfgang Wick, Michael Platten"]},"relHost":[{"language":["eng"],"disp":"K27M-mutant histone-3 as a novel target for glioma immunotherapyOncoImmunology","physDesc":[{"extent":"Online-Ressource"}],"part":{"issue":"7","year":"2017","text":"6(2017) Artikel-Nummer e1328340, 7 Seiten","volume":"6","extent":"7"},"titleAlt":[{"title":"Onco Immunology"}],"recId":"683365428","id":{"zdb":["2645309-5"],"issn":["2162-402X"],"eki":["683365428"]},"note":["Gesehen am 13.12.2022"],"origin":[{"publisher":"Taylor & Franics ; Landes Bioscience","dateIssuedDisp":"2012-","publisherPlace":"Abingdon ; Austin, Tex.","dateIssuedKey":"2012"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title":"OncoImmunology","title_sort":"OncoImmunology"}],"pubHistory":["1.2012 -"]}],"physDesc":[{"extent":"7 S."}],"language":["eng"],"person":[{"role":"aut","family":"Sahm","given":"Katharina","display":"Sahm, Katharina"},{"role":"aut","given":"Martina","family":"Ott","display":"Ott, Martina"},{"role":"aut","given":"Theresa","family":"Bunse","display":"Bunse, Theresa"},{"role":"aut","family":"Sahm","given":"Felix","display":"Sahm, Felix"},{"role":"aut","display":"Bunse, Lukas","family":"Bunse","given":"Lukas"},{"role":"aut","display":"Deumelandt, Katrin","family":"Deumelandt","given":"Katrin"},{"role":"aut","given":"Jana K.","family":"Sonner","display":"Sonner, Jana K."},{"display":"Keil, Melanie","given":"Melanie","family":"Keil","role":"aut"},{"role":"aut","family":"Deimling","given":"Andreas von","display":"Deimling, Andreas von"},{"given":"Wolfgang","family":"Wick","display":"Wick, Wolfgang","role":"aut"},{"role":"aut","given":"Michael","family":"Platten","display":"Platten, Michael"}],"title":[{"title_sort":"K27M-mutant histone-3 as a novel target for glioma immunotherapy","title":"K27M-mutant histone-3 as a novel target for glioma immunotherapy"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"05 Jul 2017"}],"note":["Gesehen am 25.04.2018"]} | ||
| SRT | |a SAHMKATHARK27MMUTANT0520 | ||