Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase

Titin-like kinases are an important class of cytoskeletal kinases that intervene in the response of muscle to mechanical stimulation, being central to myofibril homeostasis and development. These kinases exist in autoinhibited states and, allegedly, become activated during muscle activity by the ela...

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Main Authors: Castelmur, Eleonore von (Author) , Bogomolovas, Julius (Author) , Labeit, Siegfried (Author)
Format: Article (Journal)
Language:English
Published: August 21, 2012
In: Proceedings of the National Academy of Sciences of the United States of America
Year: 2012, Volume: 109, Issue: 34, Pages: 13608-13613
ISSN:1091-6490
DOI:10.1073/pnas.1200697109
Online Access:Verlag, Volltext: http://dx.doi.org/10.1073/pnas.1200697109
Verlag, Volltext: http://www.pnas.org/content/109/34/13608
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Author Notes:Eleonore von Castelmur, Johan Strümpfer, Barbara Franke, Julijus Bogomolovas, Sonia Barbieri, Hiroshi Qadota, Petr V. Konarev, Dmitri I. Svergun, Siegfried Labeit, Guy M. Benian, Klaus Schulten, Olga Mayans
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Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase by Castelmur, Eleonore von (Author) , Strumpfer, Johan (Author) , Franke, Barbara (Author) , Bogomolovas, Julius (Author) , Barbieri, Sonia (Author) , Qadota, Hiroshi (Author) , Konarev, Petr V. (Author) , Svergun, Dmitri I. (Author) , Labeit, Siegfried (Author) , Mayans, Olga (Author) ,

Bibliothek der Universität Konstanz 2012

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