The differential effect of risperidone and olanzapine on insulin sensitivity after 3 weeks of treatment: a HOMA pilot study
Background and Methods: Patients with an acute psychotic episode underwent HOMA testing for insulin sensitivity (IS) prior to and after 3 weeks of treatment with olanzapine (n=7) or risperidone (n=7). Results and Discussion: The HOMA-IS index was reduced in the olanzapine group, but significantly in...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2012
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| In: |
Pharmacopsychiatry
Year: 2012, Volume: 45, Issue: 03, Pages: 96-99 |
| ISSN: | 1439-0795 |
| DOI: | 10.1055/s-0031-1297935 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1055/s-0031-1297935 Verlag, Volltext: http://www.thieme-connect.de.ezproxy.medma.uni-heidelberg.de/DOI/DOI?10.1055/s-0031-1297935 
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| Author Notes: | G. Paslakis, M. Deuschle, J. Thome, S. Rüße, D. Kopf |
MARC
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| 245 | 1 | 4 | |a The differential effect of risperidone and olanzapine on insulin sensitivity after 3 weeks of treatment |b a HOMA pilot study |c G. Paslakis, M. Deuschle, J. Thome, S. Rüße, D. Kopf |
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| 520 | |a Background and Methods: Patients with an acute psychotic episode underwent HOMA testing for insulin sensitivity (IS) prior to and after 3 weeks of treatment with olanzapine (n=7) or risperidone (n=7). Results and Discussion: The HOMA-IS index was reduced in the olanzapine group, but significantly increased in patients treated with risperidone. There was a significant “time x medication” interaction (p=0.03). The BMI significantly increased as a result of both treatments. IS can be acutely ameliorated by antipsychotic treatment with risperidone despite weight increase. Conclusions: Compared to risperidone, the IS is impaired after a 3-week treatment with olanzapine. Already short-term antipsychotic treatment may have effects on insulin sensitivity. | ||
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