Deletion of psychiatric risk gene Cacna1c impairs hippocampal neurogenesis in cell-autonomous fashion
Ca2+ is a universal signal transducer which fulfills essential functions in cell development and differentiation. CACNA1C, the gene encoding the alpha-1C subunit (i.e., Cav1.2) of the voltage-dependent l-type calcium channel (LTCC), has been implicated as a risk gene in a variety of neuropsychiatric...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 2017
|
| In: |
Glia
Year: 2017, Jahrgang: 65, Heft: 5, Pages: 817-827 |
| ISSN: | 1098-1136 |
| DOI: | 10.1002/glia.23128 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1002/glia.23128 Verlag, Volltext: https://onlinelibrary-wiley-com.ezproxy.medma.uni-heidelberg.de/doi/abs/10.1002/glia.23128 
|
| Verfasserangaben: | Bianca Völkening, Kai Schönig, Golo Kronenberg, Dusan Bartsch, Tillmann Weber |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1572491639 | ||
| 003 | DE-627 | ||
| 005 | 20220814125822.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180430s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/glia.23128 |2 doi | |
| 035 | |a (DE-627)1572491639 | ||
| 035 | |a (DE-576)502491639 | ||
| 035 | |a (DE-599)BSZ502491639 | ||
| 035 | |a (OCoLC)1341007786 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Völkening, Bianca |e VerfasserIn |0 (DE-588)1156885469 |0 (DE-627)101984938X |0 (DE-576)502491124 |4 aut | |
| 245 | 1 | 0 | |a Deletion of psychiatric risk gene Cacna1c impairs hippocampal neurogenesis in cell-autonomous fashion |c Bianca Völkening, Kai Schönig, Golo Kronenberg, Dusan Bartsch, Tillmann Weber |
| 264 | 1 | |c May 2017 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 30.04.2018 | ||
| 520 | |a Ca2+ is a universal signal transducer which fulfills essential functions in cell development and differentiation. CACNA1C, the gene encoding the alpha-1C subunit (i.e., Cav1.2) of the voltage-dependent l-type calcium channel (LTCC), has been implicated as a risk gene in a variety of neuropsychiatric disorders. To parse the role of Cav1.2 channels located on astrocyte-like stem cells and their descendants in the development of new granule neurons, we created TgGLAST-CreERT2/Cacna1cfl/fl/RCE:loxP mice, a transgenic tool that allows cell-type-specific inducible deletion of Cacna1c. The EGFP reporter was used to trace the progeny of recombined type-1 cells. FACS-sorted Cacna1c-deficient neural precursor cells from the dentate gyrus showed reduced proliferative activity in neurosphere cultures. Moreover, under differentiation conditions, Cacna1c-deficient NPCs gave rise to fewer neurons and more astroglia. Similarly, under basal conditions in vivo, Cacna1c gene deletion in type-1 cells decreased type-1 cell proliferation and reduced the neuronal fate-choice decision of newly born cells, resulting in reduced net hippocampal neurogenesis. Unexpectedly, electroconvulsive seizures completely compensated for the proliferation deficit of Cacna1c deficient type-1 cells, indicating that there must be Cav1.2-independent mechanisms of controlling proliferation related to excitation. In the aggregate, this is the first report demonstrating the presence of functional L-type 1.2 channels on type-1 cells. Cav1.2 channels promote type-1 cell proliferation and push the glia-to-neuron ratio in the direction of a neuronal fate choice and subsequent neuronal differentiation. Cav1.2 channels expressed on NPCs and their progeny possess the ability to shape neurogenesis in a cell-autonomous fashion. | ||
| 650 | 4 | |a adult neurogenesis | |
| 650 | 4 | |a Cav1.2 | |
| 650 | 4 | |a L-type voltage gated calcium channel | |
| 650 | 4 | |a neural progenitor cell | |
| 700 | 1 | |a Bartsch, Dusan |e VerfasserIn |0 (DE-588)1035267330 |0 (DE-627)747119961 |0 (DE-576)382879007 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Glia |d Bognor Regis [u.a.] : Wiley-Liss, 1988 |g 65(2017), 5, Seite 817-827 |h Online-Ressource |w (DE-627)269532846 |w (DE-600)1474828-9 |w (DE-576)090854446 |x 1098-1136 |7 nnas |a Deletion of psychiatric risk gene Cacna1c impairs hippocampal neurogenesis in cell-autonomous fashion |
| 773 | 1 | 8 | |g volume:65 |g year:2017 |g number:5 |g pages:817-827 |g extent:11 |a Deletion of psychiatric risk gene Cacna1c impairs hippocampal neurogenesis in cell-autonomous fashion |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/glia.23128 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary-wiley-com.ezproxy.medma.uni-heidelberg.de/doi/abs/10.1002/glia.23128 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180430 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1035267330 |a Bartsch, Dusan |m 1035267330:Bartsch, Dusan |d 60000 |e 60000PB1035267330 |k 0/60000/ |p 4 | ||
| 999 | |a KXP-PPN1572491639 |e 3007627400 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"note":["Gesehen am 04.03.08"],"disp":"Deletion of psychiatric risk gene Cacna1c impairs hippocampal neurogenesis in cell-autonomous fashionGlia","type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"269532846","language":["eng"],"pubHistory":["1.1988 -"],"part":{"year":"2017","issue":"5","pages":"817-827","text":"65(2017), 5, Seite 817-827","volume":"65","extent":"11"},"title":[{"title_sort":"Glia","title":"Glia"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedKey":"1988","publisher":"Wiley-Liss","dateIssuedDisp":"1988-","publisherPlace":"Bognor Regis [u.a.]"}],"id":{"zdb":["1474828-9"],"eki":["269532846"],"doi":["10.1002/(ISSN)1098-1136"],"issn":["1098-1136"]}}],"physDesc":[{"extent":"11 S."}],"id":{"doi":["10.1002/glia.23128"],"eki":["1572491639"]},"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"May 2017"}],"name":{"displayForm":["Bianca Völkening, Kai Schönig, Golo Kronenberg, Dusan Bartsch, Tillmann Weber"]},"language":["eng"],"recId":"1572491639","note":["Gesehen am 30.04.2018"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"Deletion of psychiatric risk gene Cacna1c impairs hippocampal neurogenesis in cell-autonomous fashion","title_sort":"Deletion of psychiatric risk gene Cacna1c impairs hippocampal neurogenesis in cell-autonomous fashion"}],"person":[{"role":"aut","display":"Völkening, Bianca","roleDisplay":"VerfasserIn","given":"Bianca","family":"Völkening"},{"family":"Bartsch","given":"Dusan","roleDisplay":"VerfasserIn","display":"Bartsch, Dusan","role":"aut"}]} | ||
| SRT | |a VOELKENINGDELETIONOF2017 | ||