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Population-level decline in BMI and systolic blood pressure following mass HIV treatment: evidence from rural KwaZulu-Natal

Objective Clinic-based studies have shown that patients with human immunodeficiency virus (HIV) gain weight after initiation of antiretroviral therapy (ART). This study aimed to determine whether the scale-up of ART was associated with a population-level increase in body mass index (BMI) and blood p...

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Hauptverfasser: Geldsetzer, Pascal (VerfasserIn) , Bärnighausen, Till (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2017
In: Obesity
Year: 2016, Jahrgang: 25, Heft: 1, Pages: 200-206
ISSN:1930-739X
DOI:10.1002/oby.21663
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1002/oby.21663
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/oby.21663
Volltext
Verfasserangaben:Pascal Geldsetzer, Andrea B. Feigl, Frank Tanser, Dickman Gareta, Deenan Pillay, and Till Bärnighausen
Beschreibung
Zusammenfassung:Objective Clinic-based studies have shown that patients with human immunodeficiency virus (HIV) gain weight after initiation of antiretroviral therapy (ART). This study aimed to determine whether the scale-up of ART was associated with a population-level increase in body mass index (BMI) and blood pressure (BP) in a community with high HIV and obesity prevalence. Methods A household survey was conducted in rural KwaZulu-Natal before ART scale-up (in 2004) and when ART coverage had reached 25% (in 2010). Anthropometric data was linked with HIV surveillance data. Results Mean BMI decreased in women from 29.9 to 29.1 kg/m2 (P = 0.002) and in men from 24.2 to 23.0 kg/m2 (P < 0.001). Similarly, overweight and obesity prevalence declined significantly in both sexes. Mean systolic BP decreased from 123.0 to 118.2 mm Hg (P < 0.001) among women and 128.4 to 123.2 mm Hg (P < 0·001) among men. Conclusions Large-scale ART provision is likely to have caused a decline in BMI at the population level, because ART has improved the survival of those with substantial HIV-related weight loss. The ART scale-up may have created an unexpected opportunity to sustain population-level weight loss in communities with high HIV and obesity prevalence though targeted lifestyle and nutrition interventions.
Beschreibung:Published: 7 December 2016
Gesehen am 02.05.2018
Beschreibung:Online Resource
ISSN:1930-739X
DOI:10.1002/oby.21663

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