Low [mu]-opioid receptor status in alcohol dependence identified by combined positron emission tomography and post-mortem brain analysis
Blockade of the μ-opioid receptor (MOR) by naltrexone reduces relapse risk in a subpopulation of alcohol-dependent patients. Previous positron-emission-tomography (PET) studies using the MOR ligand [11C]carfentanil have found increased MOR availability in abstinent alcoholics, which may reflect eith...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
21 September 2016
|
| In: |
Neuropsychopharmacology
Year: 2016, Volume: 42, Issue: 3, Pages: 606-614 |
| ISSN: | 1740-634X |
| DOI: | 10.1038/npp.2016.145 |
| Online Access: | Verlag, teilw. kostenfrei, Volltext: http://dx.doi.org/10.1038/npp.2016.145 Verlag, teilw. kostenfrei, Volltext: https://www-nature-com.ezproxy.medma.uni-heidelberg.de/articles/npp2016145 
|
| Author Notes: | Derik Hermann, Natalie Hirth, Matthias Reimold, Anil Batra, Michael N. Smolka, Sabine Hoffmann, Falk Kiefer, Hamid R. Noori, Wolfgang H. Sommer, Gerald Reischl, Christian la Fougère, Karl Mann, Rainer Spanagel and Anita C. Hansson |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1572590920 | ||
| 003 | DE-627 | ||
| 005 | 20230426124312.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180503r20172016xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/npp.2016.145 |2 doi | |
| 035 | |a (DE-627)1572590920 | ||
| 035 | |a (DE-576)502590920 | ||
| 035 | |a (DE-599)BSZ502590920 | ||
| 035 | |a (OCoLC)1341008268 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hermann, Derik |d 1972- |e VerfasserIn |0 (DE-588)121855139 |0 (DE-627)705679047 |0 (DE-576)292920490 |4 aut | |
| 245 | 1 | 0 | |a Low [mu]-opioid receptor status in alcohol dependence identified by combined positron emission tomography and post-mortem brain analysis |c Derik Hermann, Natalie Hirth, Matthias Reimold, Anil Batra, Michael N. Smolka, Sabine Hoffmann, Falk Kiefer, Hamid R. Noori, Wolfgang H. Sommer, Gerald Reischl, Christian la Fougère, Karl Mann, Rainer Spanagel and Anita C. Hansson |
| 246 | 3 | 0 | |a Low mu-opioid receptor status in alcohol dependence identified by combined positron emission tomography and post-mortem brain analysis |
| 246 | 3 | 3 | |a Low μ-opioid receptor status in alcohol dependence identified by combined positron emission tomography and post-mortem brain analysis |
| 264 | 1 | |c 21 September 2016 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 03.05.2018 | ||
| 520 | |a Blockade of the μ-opioid receptor (MOR) by naltrexone reduces relapse risk in a subpopulation of alcohol-dependent patients. Previous positron-emission-tomography (PET) studies using the MOR ligand [11C]carfentanil have found increased MOR availability in abstinent alcoholics, which may reflect either increased MOR expression or lower endogenous ligand concentration. To differentiate between both effects, we investigated two cohorts of alcoholic subjects using either post-mortem or clinical PET analysis. Post-mortem brain tissue of alcohol-dependent subjects and controls (N=43/group) was quantitatively analyzed for MOR ([3H]DAMGO)-binding sites and OPRM1 mRNA in striatal regions. [11C]carfentanil PET was performed in detoxified, medication free alcohol-dependent patients (N=38), followed by a randomized controlled study of naltrexone versus placebo and follow-up for 1 year (clinical trial number: NCT00317031). Because the functional OPRM1 variant rs1799971:A>G affects the ligand binding, allele carrier status was considered in the analyses. MOR-binding sites were reduced by 23-51% in post-mortem striatal tissue of alcoholics. In the PET study, a significant interaction of OPRM1 genotype, binding potential (BPND) for [11C]carfentanil in the ventral striatum, and relapse risk was found. Particularly in G-allele carriers, lower striatal BPND was associated with a higher relapse risk. Interestingly, this effect was more pronounced in the naltrexone treatment group. Reduced MOR is interpreted as a neuroadaptation to an alcohol-induced release of endogenous ligands in patients with severe alcoholism. Low MOR availability may explain the ineffectiveness of naltrexone treatment in this subpopulation. Finally, low MOR-binding sites are proposed as a molecular marker for a negative disease course. | ||
| 534 | |c 2016 | ||
| 700 | 1 | |a Smolka, Michael |e VerfasserIn |0 (DE-588)1073229319 |0 (DE-627)828684685 |0 (DE-576)43475286X |4 aut | |
| 700 | 1 | |a Kiefer, Falk |d 1969- |e VerfasserIn |0 (DE-588)140919635 |0 (DE-627)703829033 |0 (DE-576)176310339 |4 aut | |
| 700 | 1 | |a Noori, Hamid Reza |d 1982- |e VerfasserIn |0 (DE-588)136385877 |0 (DE-627)58206872X |0 (DE-576)300993609 |4 aut | |
| 700 | 1 | |a Sommer, Wolfgang H. |e VerfasserIn |0 (DE-588)1025859626 |0 (DE-627)725315350 |0 (DE-576)370844076 |4 aut | |
| 700 | 1 | |a Mann, Karl |d 1948- |e VerfasserIn |0 (DE-588)120426455 |0 (DE-627)080667872 |0 (DE-576)187088012 |4 aut | |
| 700 | 1 | |a Spanagel, Rainer |d 1961- |e VerfasserIn |0 (DE-588)112706312 |0 (DE-627)521941261 |0 (DE-576)289740002 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neuropsychopharmacology |d London : Springer Nature, 1993 |g 42(2017), 3, Seite 606-614 |h Online-Ressource |w (DE-627)320469190 |w (DE-600)2008300-2 |w (DE-576)096188707 |x 1740-634X |7 nnas |a Low [mu]-opioid receptor status in alcohol dependence identified by combined positron emission tomography and post-mortem brain analysis |
| 773 | 1 | 8 | |g volume:42 |g year:2017 |g number:3 |g pages:606-614 |g extent:9 |a Low [mu]-opioid receptor status in alcohol dependence identified by combined positron emission tomography and post-mortem brain analysis |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/npp.2016.145 |x Verlag |x Resolving-System |z teilw. kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www-nature-com.ezproxy.medma.uni-heidelberg.de/articles/npp2016145 |x Verlag |z teilw. kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180503 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 112706312 |a Spanagel, Rainer |m 112706312:Spanagel, Rainer |d 60000 |e 60000PS112706312 |k 0/60000/ |p 13 | ||
| 998 | |g 120426455 |a Mann, Karl |m 120426455:Mann, Karl |d 60000 |e 60000PM120426455 |k 0/60000/ |p 12 | ||
| 998 | |g 1025859626 |a Sommer, Wolfgang H. |m 1025859626:Sommer, Wolfgang H. |d 60000 |e 60000PS1025859626 |k 0/60000/ |p 9 | ||
| 998 | |g 136385877 |a Noori, Hamid Reza |m 136385877:Noori, Hamid Reza |d 60000 |e 60000PN136385877 |k 0/60000/ |p 8 | ||
| 998 | |g 140919635 |a Kiefer, Falk |m 140919635:Kiefer, Falk |d 60000 |e 60000PK140919635 |k 0/60000/ |p 7 | ||
| 998 | |g 1073229319 |a Smolka, Michael |m 1073229319:Smolka, Michael |d 60000 |e 60000PS1073229319 |k 0/60000/ |p 5 | ||
| 998 | |g 121855139 |a Hermann, Derik |m 121855139:Hermann, Derik |d 60000 |e 60000PH121855139 |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1572590920 |e 3007842972 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"titleAlt":[{"title":"Low μ-opioid receptor status in alcohol dependence identified by combined positron emission tomography and post-mortem brain analysis"}],"origin":[{"dateIssuedDisp":"21 September 2016","dateIssuedKey":"2017"}],"physDesc":[{"extent":"9 S."}],"id":{"doi":["10.1038/npp.2016.145"],"eki":["1572590920"]},"relHost":[{"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["Nachgewiesen 8.1993 -"],"part":{"year":"2017","issue":"3","text":"42(2017), 3, Seite 606-614","extent":"9","pages":"606-614","volume":"42"},"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"London ; Amsterdam [u.a.] ; London","dateIssuedDisp":"1993-","dateIssuedKey":"1993","publisher":"Springer Nature ; Elsevier Science ; Nature Publ. Group"}],"note":["Ungezählte Beil.: Supplement"],"id":{"issn":["1740-634X"],"eki":["320469190"],"zdb":["2008300-2"]},"recId":"320469190","disp":"Low [mu]-opioid receptor status in alcohol dependence identified by combined positron emission tomography and post-mortem brain analysisNeuropsychopharmacology","language":["eng"],"title":[{"title":"Neuropsychopharmacology","subtitle":"official publication of the American College of Neuropsychopharmacology","title_sort":"Neuropsychopharmacology"}]}],"recId":"1572590920","person":[{"given":"Derik","roleDisplay":"VerfasserIn","role":"aut","family":"Hermann","display":"Hermann, Derik"},{"display":"Smolka, Michael","family":"Smolka","role":"aut","roleDisplay":"VerfasserIn","given":"Michael"},{"display":"Kiefer, Falk","family":"Kiefer","role":"aut","roleDisplay":"VerfasserIn","given":"Falk"},{"role":"aut","roleDisplay":"VerfasserIn","family":"Noori","display":"Noori, Hamid Reza","given":"Hamid Reza"},{"given":"Wolfgang H.","family":"Sommer","display":"Sommer, Wolfgang H.","role":"aut","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Mann, Karl","family":"Mann","given":"Karl"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Spanagel, Rainer","family":"Spanagel","given":"Rainer"}],"note":["Gesehen am 03.05.2018"],"language":["eng"],"name":{"displayForm":["Derik Hermann, Natalie Hirth, Matthias Reimold, Anil Batra, Michael N. Smolka, Sabine Hoffmann, Falk Kiefer, Hamid R. Noori, Wolfgang H. Sommer, Gerald Reischl, Christian la Fougère, Karl Mann, Rainer Spanagel and Anita C. Hansson"]},"title":[{"title_sort":"Low [mu]-opioid receptor status in alcohol dependence identified by combined positron emission tomography and post-mortem brain analysis","title":"Low [mu]-opioid receptor status in alcohol dependence identified by combined positron emission tomography and post-mortem brain analysis"}]} | ||
| SRT | |a HERMANNDERLOWMUOPIOI2120 | ||