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Ki-67 expression predicts radiosensitivity in oral squamous cell carcinoma

The prognostic relevance of Ki-67 expression in oral squamous cell carcinoma (OSCC) is still controversial. As proliferating cells are more susceptible to ionizing radiation, the authors investigated if a high proliferation rate reflected by Ki-67 expression, predicts radiosensitivity in OSCC patien...

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Main Authors: Freudlsperger, Christian (Author) , Freier, Kolja (Author) , Hoffmann, Jürgen (Author) , Engel, Michael (Author)
Format: Article (Journal)
Language:English
Published: 14 May 2012
In: International journal of oral and maxillofacial surgery
Year: 2012, Volume: 41, Issue: 8, Pages: 965-969
ISSN:1399-0020
DOI:10.1016/j.ijom.2012.04.014
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.ijom.2012.04.014
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0901502712001695
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Author Notes:C. Freudlsperger, K. Freier, J. Hoffmann, M. Engel

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520 |a The prognostic relevance of Ki-67 expression in oral squamous cell carcinoma (OSCC) is still controversial. As proliferating cells are more susceptible to ionizing radiation, the authors investigated if a high proliferation rate reflected by Ki-67 expression, predicts radiosensitivity in OSCC patients. In 52 patients with OSCC who received primary surgery followed by radiation therapy, the proliferation rate was assessed by Ki-67 immunhistochemistry and correlated to recurrent free survival and overall survival. Low proliferative carcinomas showed a significantly shorter mean time to recurrence of 27.5 months compared to 49.5 months of high proliferative tumours (p=0.048). The 5-year survival rate of low proliferative tumours was 49% compared to 80% for high proliferative tumours (p=0.042). This study indicates that tumours with high proliferative activity are more susceptible to radiation therapy. Ki-67 might be used as a marker to predict the response to radiation therapy in patients with OSCC. 
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