Ki-67 expression predicts radiosensitivity in oral squamous cell carcinoma
The prognostic relevance of Ki-67 expression in oral squamous cell carcinoma (OSCC) is still controversial. As proliferating cells are more susceptible to ionizing radiation, the authors investigated if a high proliferation rate reflected by Ki-67 expression, predicts radiosensitivity in OSCC patien...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
14 May 2012
|
| In: |
International journal of oral and maxillofacial surgery
Year: 2012, Volume: 41, Issue: 8, Pages: 965-969 |
| ISSN: | 1399-0020 |
| DOI: | 10.1016/j.ijom.2012.04.014 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.ijom.2012.04.014 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0901502712001695 
|
| Author Notes: | C. Freudlsperger, K. Freier, J. Hoffmann, M. Engel |
| Summary: | The prognostic relevance of Ki-67 expression in oral squamous cell carcinoma (OSCC) is still controversial. As proliferating cells are more susceptible to ionizing radiation, the authors investigated if a high proliferation rate reflected by Ki-67 expression, predicts radiosensitivity in OSCC patients. In 52 patients with OSCC who received primary surgery followed by radiation therapy, the proliferation rate was assessed by Ki-67 immunhistochemistry and correlated to recurrent free survival and overall survival. Low proliferative carcinomas showed a significantly shorter mean time to recurrence of 27.5 months compared to 49.5 months of high proliferative tumours (p=0.048). The 5-year survival rate of low proliferative tumours was 49% compared to 80% for high proliferative tumours (p=0.042). This study indicates that tumours with high proliferative activity are more susceptible to radiation therapy. Ki-67 might be used as a marker to predict the response to radiation therapy in patients with OSCC. |
|---|---|
| Item Description: | Gesehen am 03.05.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1399-0020 |
| DOI: | 10.1016/j.ijom.2012.04.014 |