Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2
The nuclear cap-binding complex (CBC) binds to the 5′-cap structure of Pol II transcripts. Here, the authors give structural insights into CBC-mediated transcript processing and show that CBC forms mutual exclusive complexes with NELF and ARS2, which might act in earlier and later phases of transcri...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
03 November 2017
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| In: |
Nature Communications
Year: 2017, Jahrgang: 8, Heft: 1 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-017-01402-w |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/s41467-017-01402-w Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-017-01402-w 
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| Verfasserangaben: | Wiebke Manuela Schulze and Stephen Cusack |
| Zusammenfassung: | The nuclear cap-binding complex (CBC) binds to the 5′-cap structure of Pol II transcripts. Here, the authors give structural insights into CBC-mediated transcript processing and show that CBC forms mutual exclusive complexes with NELF and ARS2, which might act in earlier and later phases of transcription, respectively. |
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| Beschreibung: | Gesehen am 07.05.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-017-01402-w |