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HLA haplotypes in primary sclerosing cholangitis patients of admixed and non‐European ancestry

Primary sclerosing cholangitis (PSC) is strongly associated with several human leukocyte antigen (HLA) haplotypes. Due to extensive linkage disequilibrium and multiple polymorphic candidate genes in the HLA complex, identifying the alleles responsible for these associations has proven difficult. We...

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Bibliographic Details
Main Authors: Henriksen, Ellen Karoline (Author) , Gotthardt, Daniel (Author)
Format: Article (Journal)
Language:English
Published: 11 July 2017
In: HLA
Year: 2017, Volume: 90, Issue: 4, Pages: 228-233
ISSN:2059-2310
DOI:10.1111/tan.13076
Online Access:Verlag, kostenfrei registrierungspflichtig, Volltext: http://dx.doi.org/10.1111/tan.13076
Verlag, kostenfrei registrierungspflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/tan.13076
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Author Notes:E.K.K. Henriksen, M.K. Viken, M. Wittig, K. Holm, T. Folseraas, S. Mucha, E. Melum, J.R. Hov, K.N. Lazaridis, B.D. Juran, O. Chazouillères, M. Färkkilä, D.N. Gotthardt, P. Invernizzi, M. Carbone, G.M. Hirschfield, S.M. Rushbrook, E. Goode, C.Y. Ponsioen, R.K. Weersma, B. Eksteen, K.K. Yimam, S.C. Gordon, D. Goldberg, L. Yu, C.L. Bowlus, A. Franke, B.A. Lie, T.H. Karlsen
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Summary:Primary sclerosing cholangitis (PSC) is strongly associated with several human leukocyte antigen (HLA) haplotypes. Due to extensive linkage disequilibrium and multiple polymorphic candidate genes in the HLA complex, identifying the alleles responsible for these associations has proven difficult. We aimed to evaluate whether studying populations of admixed or non-European descent could help in defining the causative HLA alleles. When assessing haplotypes carrying HLA-DRB1*13:01 (hypothesized to specifically increase the susceptibility to chronic cholangitis), we observed that every haplotype in the Scandinavian PSC population carried HLA-DQB1*06:03. In contrast, only 65% of HLA-DRB1*13:01 haplotypes in an admixed/non-European PSC population carried this allele, suggesting that further assessments of the PSC-associated haplotype HLA-DRB1*13:01?DQA1*01:03-DQB1*06:03 in admixed or multi?ethnic populations could aid in identifying the causative allele.
Item Description:Gesehen am 07.05.2018
Physical Description:Online Resource
ISSN:2059-2310
DOI:10.1111/tan.13076

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