Longer duration of obesity is associated with a reduction in urinary angiotensinogen in prepubertal children
BackgroundWe aimed to study the impact of obesity on urinary excretion of angiotensinogen (U-AGT) in prepubertal children, focusing on the duration of obesity and gender. Also, we aimed to evaluate whether plasma angiotensinogen (P-AGT) and hydrogen peroxide (H2O2) play a role in the putative associ...
Gespeichert in:
| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 March 2017
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| In: |
Pediatric nephrology
Year: 2017, Jahrgang: 32, Heft: 8, Pages: 1411-1422 |
| ISSN: | 1432-198X |
| DOI: | 10.1007/s00467-017-3639-y |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1007/s00467-017-3639-y Verlag, Volltext: https://link.springer.com/article/10.1007/s00467-017-3639-y 
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| Verfasserangaben: | Manuela Morato, Liane Correia-Costa, Teresa Sousa, Dina Cosme, Franz Schaefer, José Carlos Areias, António Guerra, Alberto Caldas Afonso, Henrique Barros, Ana Azevedo, António Albino-Teixeira |
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| 520 | |a BackgroundWe aimed to study the impact of obesity on urinary excretion of angiotensinogen (U-AGT) in prepubertal children, focusing on the duration of obesity and gender. Also, we aimed to evaluate whether plasma angiotensinogen (P-AGT) and hydrogen peroxide (H2O2) play a role in the putative association.MethodsCross-sectional evaluation of 305 children aged 8-9 years (160 normal weight, 86 overweight, and 59 obese). Anthropometric measurements and 24-h ambulatory blood pressure monitoring were performed. Angiotensinogen (AGT) was determined by a commercial enzyme-linked immunosorbent assay (ELISA) kit and H2O2 by a microplate fluorometric assay.ResultsU-AGT and P-AGT levels were similar across body mass index (BMI) groups and between sexes. However, boys who were overweight/obese since the age of 4 years presented lower levels of U-AGT compared with those of normal weight at the same age. In children who were overweight/obese since the age of 4, urinary H2O2 decreased with P-AGT.ConclusionsA higher duration of obesity was associated with decreased U-AGT in boys, thus reflecting decreased intrarenal activity of the renin-angiotensin system. Also, children with a longer duration of obesity showed an inverse association between urinary H2O2 and P-AGT. Future studies should address whether these results reflect an early compensatory mechanism to limit obesity-triggered renal dysfunction. | ||
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