Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes
An efficient procedure for the concise synthesis of hetero-bis-metallated alkenes as useful building blocks for the modular access to highly elaborate polyenes and stabilized analogues is reported. By applying these bifunctional olefins in convergent Stille/Suzuki-Miyaura couplings, novel, carefully...
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2013
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| In: |
Organic & biomolecular chemistry
Year: 2012, Jahrgang: 11, Heft: 13, Pages: 2116-2139 |
| ISSN: | 1477-0539 |
| DOI: | 10.1039/c2ob26906f |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1039/c2ob26906f
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| Verfasserangaben: | Mario Altendorfer, Aruna Raja, Florenz Sasse, Herbert Irschik and Dirk Menche |
| Zusammenfassung: | An efficient procedure for the concise synthesis of hetero-bis-metallated alkenes as useful building blocks for the modular access to highly elaborate polyenes and stabilized analogues is reported. By applying these bifunctional olefins in convergent Stille/Suzuki-Miyaura couplings, novel, carefully selected side chain analogues of the potent RNA polymerase inhibitor etnangien were synthesized by a modular late stage coupling strategy and evaluated for antibacterial and antiproliferative activities. |
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| Beschreibung: | Published online: 19 November 2012 Gesehen am 08.05.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1477-0539 |
| DOI: | 10.1039/c2ob26906f |