Net clinical benefit of rivaroxaban compared with warfarin in atrial fibrillation: results from ROCKET AF
Aims: The aim of this study was to determine the net clinical benefit (NCB) of rivaroxaban compared with warfarin in patients with atrial fibrillation. Methods: This was a retrospective analysis of 14,236 patients included in ROCKET AF who received at least one dose of study drug. We analyzed NCB us...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
6 March 2018
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| In: |
International journal of cardiology
Year: 2018, Jahrgang: 257, Pages: 78-83 |
| ISSN: | 1874-1754 |
| DOI: | 10.1016/j.ijcard.2017.06.110 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.ijcard.2017.06.110 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0167527317329716 
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| Verfasserangaben: | Adam S. Barnett, Derek D. Cyr, Shaun G. Goodman, Bennett S. Levitan, Zhong Yuan, Graeme J. Hankey, Daniel E. Singer, Richard C. Becker, Günter Breithardt, Scott D. Berkowitz, Jonathan L. Halperin, Werner Hacke, Kenneth W. Mahaffey, Christopher C. Nessel, Keith A.A. Fox, Manesh R. Patel, Jonathan P. Piccini |
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| 245 | 1 | 0 | |a Net clinical benefit of rivaroxaban compared with warfarin in atrial fibrillation |b results from ROCKET AF |c Adam S. Barnett, Derek D. Cyr, Shaun G. Goodman, Bennett S. Levitan, Zhong Yuan, Graeme J. Hankey, Daniel E. Singer, Richard C. Becker, Günter Breithardt, Scott D. Berkowitz, Jonathan L. Halperin, Werner Hacke, Kenneth W. Mahaffey, Christopher C. Nessel, Keith A.A. Fox, Manesh R. Patel, Jonathan P. Piccini |
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| 520 | |a Aims: The aim of this study was to determine the net clinical benefit (NCB) of rivaroxaban compared with warfarin in patients with atrial fibrillation. Methods: This was a retrospective analysis of 14,236 patients included in ROCKET AF who received at least one dose of study drug. We analyzed NCB using four different methods: (1) composite of death, stroke, systemic embolism, myocardial infarction, and major bleeding; (2) method 1 with fatal or critical organ bleeding substituted for major bleeding; (3) difference between the rate of ischemic stroke or systemic embolism minus 1.5 times the difference between the rate of intracranial hemorrhage; and (4) weighted sum of differences between rates of death, ischemic stroke or systemic embolism, intracranial hemorrhage, and major bleeding. Results: Rivaroxaban was associated with a lower risk of the composite outcome of death, myocardial infarction, stroke, or systemic embolism (rate difference per 10,000 patient-years [RD]=−86.8 [95% CI −143.6 to −30.0]) and fatal or critical organ bleeding (−41.3 [−68 to −14.7]). However, rivaroxaban was associated with a higher risk of major bleeding other than fatal or critical organ bleeding (55.9 [14.7 to 97.2]). Method 1 showed no difference between treatments (−35.5 [−108.4 to 37.3]). Methods 2-4 favored treatment with rivaroxaban (2: −96.8 [−157.0 to −36.8]; 3: −65.2 [−112.3 to −17.8]; 4: −54.8 [−96.0 to −10.2]). Conclusions: Rivaroxaban was associated with favorable NCB compared with warfarin. The NCB was attributable to lower rates of ischemic events and fatal or critical organ bleeding. | ||
| 650 | 4 | |a Atrial fibrillation | |
| 650 | 4 | |a Net clinical benefit | |
| 650 | 4 | |a Rivaroxaban | |
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