Tune it down to live it up?: rapid, nongenomic effects of cortisol on the human brain
The stress hormone cortisol acts on the brain, supporting adaptation and time-adjusted coping processes. Whereas previous research has focused on slow emerging, genomic effects of cortisol, we addressed the rapid, nongenomic cortisol effects on in vivo neuronal activity in humans. Three independent...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January 11, 2012
|
| In: |
The journal of neuroscience
Year: 2012, Jahrgang: 32, Heft: 2, Pages: 616-625 |
| ISSN: | 1529-2401 |
| DOI: | 10.1523/JNEUROSCI.2384-11.2012 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1523/JNEUROSCI.2384-11.2012 Verlag, Volltext: http://www.jneurosci.org/content/32/2/616 
|
| Verfasserangaben: | Florian Strelzyk, Michael Hermes, Ewald Naumann, Melly Oitzl, Christoph Walter, Hans-Peter Busch, Steffen Richter, and Hartmut Schächinger |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1574277065 | ||
| 003 | DE-627 | ||
| 005 | 20220814134620.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180508s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1523/JNEUROSCI.2384-11.2012 |2 doi | |
| 035 | |a (DE-627)1574277065 | ||
| 035 | |a (DE-576)504277065 | ||
| 035 | |a (DE-599)BSZ504277065 | ||
| 035 | |a (OCoLC)1341009374 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Strelzyk, Florian |d 1983- |e VerfasserIn |0 (DE-588)1014225809 |0 (DE-627)666264023 |0 (DE-576)348467923 |4 aut | |
| 245 | 1 | 0 | |a Tune it down to live it up? |b rapid, nongenomic effects of cortisol on the human brain |c Florian Strelzyk, Michael Hermes, Ewald Naumann, Melly Oitzl, Christoph Walter, Hans-Peter Busch, Steffen Richter, and Hartmut Schächinger |
| 264 | 1 | |c January 11, 2012 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.08.2020 | ||
| 520 | |a The stress hormone cortisol acts on the brain, supporting adaptation and time-adjusted coping processes. Whereas previous research has focused on slow emerging, genomic effects of cortisol, we addressed the rapid, nongenomic cortisol effects on in vivo neuronal activity in humans. Three independent placebo-controlled studies in healthy men were conducted. We observed changes in CNS activity within 15 min after intravenous administration of a physiological dose of 4 mg of cortisol (hydrocortisone). Two of the studies demonstrated a rapid bilateral thalamic perfusion decrement using continuous arterial spin labeling. The third study revealed rapid, cortisol-induced changes in global signal strength and map dissimilarity of the electroencephalogram. Our data demonstrate that a physiological concentration of cortisol profoundly affects the functioning and perfusion of the human brain in vivo via a rapid, nongenomic mechanism. The changes in neuronal functioning suggest that cortisol acts on the thalamic relay of background as well as on task-specific sensory information, allowing focus and facilitation of adaptation to challenges. | ||
| 700 | 1 | |a Hermes, Michael |e VerfasserIn |0 (DE-588)134155971 |0 (DE-627)562104836 |0 (DE-576)300346530 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of neuroscience |d Washington, DC : Soc., 1981 |g 32(2012), 2, Seite 616-625 |h Online-Ressource |w (DE-627)269536906 |w (DE-600)1475274-8 |w (DE-576)078590124 |x 1529-2401 |7 nnas |a Tune it down to live it up? rapid, nongenomic effects of cortisol on the human brain |
| 773 | 1 | 8 | |g volume:32 |g year:2012 |g number:2 |g pages:616-625 |g extent:10 |a Tune it down to live it up? rapid, nongenomic effects of cortisol on the human brain |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1523/JNEUROSCI.2384-11.2012 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.jneurosci.org/content/32/2/616 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180508 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 134155971 |a Hermes, Michael |m 134155971:Hermes, Michael |d 100000 |d 100200 |e 100000PH134155971 |e 100200PH134155971 |k 0/100000/ |k 1/100000/100200/ |p 2 | ||
| 999 | |a KXP-PPN1574277065 |e 3008542271 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 25.08.2020"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"recId":"1574277065","title":[{"title_sort":"Tune it down to live it up?","title":"Tune it down to live it up?","subtitle":"rapid, nongenomic effects of cortisol on the human brain"}],"person":[{"display":"Strelzyk, Florian","roleDisplay":"VerfasserIn","role":"aut","family":"Strelzyk","given":"Florian"},{"given":"Michael","family":"Hermes","role":"aut","roleDisplay":"VerfasserIn","display":"Hermes, Michael"}],"physDesc":[{"extent":"10 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisher":"Soc.","dateIssuedKey":"1981","dateIssuedDisp":"1981-","publisherPlace":"Washington, DC"}],"id":{"issn":["1529-2401"],"eki":["269536906"],"zdb":["1475274-8"]},"pubHistory":["1.1981 -"],"titleAlt":[{"title":"Neuroscience"},{"title":"JNeurosci"}],"part":{"pages":"616-625","issue":"2","year":"2012","extent":"10","volume":"32","text":"32(2012), 2, Seite 616-625"},"disp":"Tune it down to live it up? rapid, nongenomic effects of cortisol on the human brainThe journal of neuroscience","note":["Fortsetzung der Druck-Ausgabe","Gesehen am 07.11.2022"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"269536906","language":["eng"],"corporate":[{"roleDisplay":"Herausgebendes Organ","display":"Society for Neuroscience","role":"isb"}],"title":[{"title":"The journal of neuroscience","subtitle":"the official journal of the Society for Neuroscience","title_sort":"journal of neuroscience"}]}],"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"January 11, 2012"}],"id":{"doi":["10.1523/JNEUROSCI.2384-11.2012"],"eki":["1574277065"]},"name":{"displayForm":["Florian Strelzyk, Michael Hermes, Ewald Naumann, Melly Oitzl, Christoph Walter, Hans-Peter Busch, Steffen Richter, and Hartmut Schächinger"]}} | ||
| SRT | |a STRELZYKFLTUNEITDOWN1120 | ||