Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth
Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of myeloid cells in cancer patients and tumor-bearing mice that potently inhibits T cell responses. During tumor progression, MDSCs accumulate in several organs, including the tumor tissue. So far, tumor-infiltrating MDSC...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2012
|
| In: |
The journal of immunology
Year: 2012, Jahrgang: 189, Heft: 12, Pages: 5602-5611 |
| ISSN: | 1550-6606 |
| DOI: | 10.4049/jimmunol.1201018 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.4049/jimmunol.1201018 Verlag, kostenfrei, Volltext: http://www.jimmunol.org/content/189/12/5602 
|
| Verfasserangaben: | Eva Schlecker, Ana Stojanovic, Christian Eisen, Christian Quack, Christine S. Falk, Viktor Umansky, and Adelheid Cerwenka |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1574284169 | ||
| 003 | DE-627 | ||
| 005 | 20220814134814.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180509s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.4049/jimmunol.1201018 |2 doi | |
| 035 | |a (DE-627)1574284169 | ||
| 035 | |a (DE-576)504284169 | ||
| 035 | |a (DE-599)BSZ504284169 | ||
| 035 | |a (OCoLC)1341009396 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schlecker, Eva |e VerfasserIn |0 (DE-588)1014392624 |0 (DE-627)666970564 |0 (DE-576)348712502 |4 aut | |
| 245 | 1 | 0 | |a Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth |c Eva Schlecker, Ana Stojanovic, Christian Eisen, Christian Quack, Christine S. Falk, Viktor Umansky, and Adelheid Cerwenka |
| 264 | 1 | |c 2012 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 09.05.2018 | ||
| 520 | |a Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of myeloid cells in cancer patients and tumor-bearing mice that potently inhibits T cell responses. During tumor progression, MDSCs accumulate in several organs, including the tumor tissue. So far, tumor-infiltrating MDSC subpopulations remain poorly explored. In this study, we performed global gene expression profiling of mouse tumor-infiltrating granulocytic and monocytic (MO-MDSC) subsets compared with MDSCs from peripheral blood. RMA-S lymphoma-infiltrating MO-MDSCs not only produced high levels of NO and arginase-1, but also greatly increased levels of chemokines comprising the CCR5 ligands CCL3, CCL4, and CCL5. MO-MDSCs isolated from B16 melanoma and from skin tumor-bearing ret transgenic mice also expressed high levels of CCL3, CCL4, and CCL5. Expression of CCR5 was preferentially detected on regulatory T cells (Tregs). Accordingly, tumor-infiltrating MO-MDSCs directly attracted high numbers of Tregs via CCR5 in vitro. Intratumoral injection of CCL4 or CCL5 increased tumor-infiltrating Tregs, and deficiency of CCR5 led to their profound decrease. Moreover, in CCR5-deficient mice, RMA-S and B16 tumor growth was delayed emphasizing the importance of CCR5 in the control of antitumor immune responses. Overall, our data demonstrate that chemokines secreted by tumor-infiltrating MO-MDSCs recruit high numbers of Tregs revealing a novel suppressive role of MDSCs with potential clinical implications for the development of cancer immunotherapies. | ||
| 700 | 1 | |a Umansky, Viktor |d 1955- |e VerfasserIn |0 (DE-588)102885756X |0 (DE-627)731733207 |0 (DE-576)376300078 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of immunology |d Rockville, Md. : American Association of Immunologists, 1916 |g 189(2012), 12, Seite 5602-5611 |h Online-Ressource |w (DE-627)269535217 |w (DE-600)1475085-5 |w (DE-576)079963838 |x 1550-6606 |7 nnas |a Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth |
| 773 | 1 | 8 | |g volume:189 |g year:2012 |g number:12 |g pages:5602-5611 |g extent:10 |a Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth |
| 856 | 4 | 0 | |u http://dx.doi.org/10.4049/jimmunol.1201018 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://www.jimmunol.org/content/189/12/5602 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180509 | ||
| 993 | |a Article | ||
| 998 | |g 102885756X |a Umansky, Viktor |m 102885756X:Umansky, Viktor |d 60000 |d 61900 |d 140000 |e 60000PU102885756X |e 61900PU102885756X |e 140000PU102885756X |k 0/60000/ |k 1/60000/61900/ |k 0/140000/ |p 6 | ||
| 999 | |a KXP-PPN1574284169 |e 3008695957 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"recId":"1574284169","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 09.05.2018"],"person":[{"family":"Schlecker","given":"Eva","display":"Schlecker, Eva","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Umansky","given":"Viktor","roleDisplay":"VerfasserIn","display":"Umansky, Viktor","role":"aut"}],"title":[{"title":"Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth","title_sort":"Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth"}],"relHost":[{"part":{"extent":"10","volume":"189","text":"189(2012), 12, Seite 5602-5611","pages":"5602-5611","issue":"12","year":"2012"},"pubHistory":["1.1916 -"],"recId":"269535217","corporate":[{"role":"isb","roleDisplay":"Herausgebendes Organ","display":"American Association of Immunologists"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growthThe journal of immunology","note":["Gesehen am 18.08.2025"],"title":[{"title":"The journal of immunology","title_sort":"journal of immunology"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1550-6606"],"eki":["269535217"],"zdb":["1475085-5"]},"origin":[{"publisher":"Oxford University Press ; Soc. ; American Association of Immunologists","dateIssuedKey":"2025","dateIssuedDisp":"2025-","publisherPlace":"Oxford ; Bethesda, Md. ; Rockville, Md."}],"name":{"displayForm":["American Association of Immunologists"]}}],"physDesc":[{"extent":"10 S."}],"name":{"displayForm":["Eva Schlecker, Ana Stojanovic, Christian Eisen, Christian Quack, Christine S. Falk, Viktor Umansky, and Adelheid Cerwenka"]},"id":{"eki":["1574284169"],"doi":["10.4049/jimmunol.1201018"]},"origin":[{"dateIssuedDisp":"2012","dateIssuedKey":"2012"}]} | ||
| SRT | |a SCHLECKERETUMORINFIL2012 | ||