Efficient synthesis of diverse hetero-bis-metallated alkenes as modular reagents towards highly conjugated and isolated olefinic systems
An efficient synthesis of diverse hetero-bis-metallated alkenes with conjugated and isolated olefin subunits is reported. Relying on those useful tin/boron reagents a convergent, palladium-catalyzed fragment coupling strategy has been developed as an elegant methodology to construct highly conjugate...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2 July 2012
|
| In: |
Chemical communications
Year: 2012, Volume: 48, Issue: 66, Pages: 8267-8269 |
| ISSN: | 1364-548X |
| DOI: | 10.1039/C2CC34052F |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1039/C2CC34052F Verlag, Volltext: http://pubs.rsc.org/en/content/articlelanding/2012/cc/c2cc34052f 
|
| Author Notes: | Mario Altendorfer, Dirk Menche |
| Summary: | An efficient synthesis of diverse hetero-bis-metallated alkenes with conjugated and isolated olefin subunits is reported. Relying on those useful tin/boron reagents a convergent, palladium-catalyzed fragment coupling strategy has been developed as an elegant methodology to construct highly conjugated polyenes and stabilized olefinic analogues thereof. The utility of these reagents was further demonstrated in a concise and modular construction of extended polyene side chains of the potent polyketide antibiotic etnangien. |
|---|---|
| Item Description: | Gesehen am 09.05.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1364-548X |
| DOI: | 10.1039/C2CC34052F |