Disruptions in the left frontoparietal network underlie resting state endophenotypic markers in schizophrenia
Advances in functional brain imaging have improved the search for potential endophenotypic markers in schizophrenia. Here, we employed independent component analysis (ICA) and dynamic causal modeling (DCM) in resting state fMRI on a sample of 35 schizophrenia patients, 20 first-degree relatives and...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2016
|
| In: |
Human brain mapping
Year: 2016, Jahrgang: 38, Heft: 4, Pages: 1741-1750 |
| ISSN: | 1097-0193 |
| DOI: | 10.1002/hbm.23477 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1002/hbm.23477 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.23477 
|
| Verfasserangaben: | George Chahine, Anja Richter, Sarah Wolter, Roberto Goya‐Maldonado, Oliver Gruber |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1574984802 | ||
| 003 | DE-627 | ||
| 005 | 20220814135725.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180511r20162016xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/hbm.23477 |2 doi | |
| 035 | |a (DE-627)1574984802 | ||
| 035 | |a (DE-576)504984802 | ||
| 035 | |a (DE-599)BSZ504984802 | ||
| 035 | |a (OCoLC)1341009522 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Chahine, Georges |e VerfasserIn |4 aut | |
| 245 | 1 | 0 | |a Disruptions in the left frontoparietal network underlie resting state endophenotypic markers in schizophrenia |c George Chahine, Anja Richter, Sarah Wolter, Roberto Goya‐Maldonado, Oliver Gruber |
| 264 | 1 | |c 2016 | |
| 300 | |a 4 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online: 23 December 2016 | ||
| 500 | |a Gesehen am 11.05.2018 | ||
| 520 | |a Advances in functional brain imaging have improved the search for potential endophenotypic markers in schizophrenia. Here, we employed independent component analysis (ICA) and dynamic causal modeling (DCM) in resting state fMRI on a sample of 35 schizophrenia patients, 20 first-degree relatives and 35 control subjects. Analysis on ICA-derived networks revealed increased functional connectivity between the left frontoparietal network (FPN) and left temporal and parietal regions in schizophrenia patients (P < 0.001). First-degree relatives shared this hyperconnectivity, in particular in the supramarginal gyrus (SMG; P = 0.008). DCM analysis was employed to further explore underlying effective connectivity. Results showed increased inhibitory connections to the left angular gyrus (AG) in schizophrenia patients from all other nodes of the left FPN (P < 0.001), and in particular from the left SMG (P = 0.001). Relatives also showed a pattern of increased inhibitory connections to the left AG (P = 0.008). Furthermore, the patient group showed increased excitatory connectivity between the left fusiform gyrus and the left SMG (P = 0.002). This connection was negatively correlated to inhibitory afferents to the left AG (P = 0.005) and to the negative symptom score on the PANSS scale (P = 0.001, r = −0.51). Left frontoparietotemporal dysfunction in schizophrenia has been previously associated with a range of abnormalities, including formal thought disorder, working memory dysfunction and sensory hallucinations. Our analysis uncovered new potential endophenotypic markers of schizophrenia and shed light on the organization of the left FPN in patients and their first-degree relatives. Hum Brain Mapp 38:1741-1750, 2017. © 2017 Wiley Periodicals, Inc. | ||
| 534 | |c 2016 | ||
| 650 | 4 | |a biomarker | |
| 650 | 4 | |a endophenotypes | |
| 650 | 4 | |a neuroimaging | |
| 650 | 4 | |a schizophrenia | |
| 700 | 1 | |a Richter, Anja |d 1968- |e VerfasserIn |0 (DE-588)17356898X |0 (DE-627)698479920 |0 (DE-576)134412958 |4 aut | |
| 700 | 1 | |a Gruber, Oliver |d 1968- |e VerfasserIn |0 (DE-588)121160793 |0 (DE-627)08112502X |0 (DE-576)292563590 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Human brain mapping |d New York, NY : Wiley-Liss, 1993 |g 38(2017), 4, Seite 1741-1750 |h Online-Ressource |w (DE-627)302922911 |w (DE-600)1492703-2 |w (DE-576)090855248 |x 1097-0193 |7 nnas |a Disruptions in the left frontoparietal network underlie resting state endophenotypic markers in schizophrenia |
| 773 | 1 | 8 | |g volume:38 |g year:2017 |g number:4 |g pages:1741-1750 |g extent:4 |a Disruptions in the left frontoparietal network underlie resting state endophenotypic markers in schizophrenia |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/hbm.23477 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.23477 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180511 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 121160793 |a Gruber, Oliver |m 121160793:Gruber, Oliver |d 910000 |d 910600 |e 910000PG121160793 |e 910600PG121160793 |k 0/910000/ |k 1/910000/910600/ |p 5 |y j | ||
| 998 | |g 17356898X |a Richter, Anja |m 17356898X:Richter, Anja |d 910000 |d 910600 |e 910000PR17356898X |e 910600PR17356898X |k 0/910000/ |k 1/910000/910600/ |p 2 | ||
| 999 | |a KXP-PPN1574984802 |e 3009147864 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Disruptions in the left frontoparietal network underlie resting state endophenotypic markers in schizophrenia","title":"Disruptions in the left frontoparietal network underlie resting state endophenotypic markers in schizophrenia"}],"language":["eng"],"name":{"displayForm":["George Chahine, Anja Richter, Sarah Wolter, Roberto Goya‐Maldonado, Oliver Gruber"]},"person":[{"display":"Chahine, Georges","given":"Georges","role":"aut","family":"Chahine"},{"display":"Richter, Anja","given":"Anja","role":"aut","family":"Richter"},{"display":"Gruber, Oliver","role":"aut","given":"Oliver","family":"Gruber"}],"origin":[{"dateIssuedDisp":"2016","dateIssuedKey":"2016"}],"recId":"1574984802","type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"4 S."}],"id":{"doi":["10.1002/hbm.23477"],"eki":["1574984802"]},"relHost":[{"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"publisherPlace":"New York, NY","dateIssuedKey":"1993","publisher":"Wiley-Liss","dateIssuedDisp":"1993-"}],"recId":"302922911","note":["Gesehen am 11.10.05"],"id":{"eki":["302922911"],"zdb":["1492703-2"],"issn":["1097-0193"],"doi":["10.1002/(ISSN)1097-0193"]},"physDesc":[{"extent":"Online-Ressource"}],"disp":"Disruptions in the left frontoparietal network underlie resting state endophenotypic markers in schizophreniaHuman brain mapping","language":["eng"],"part":{"volume":"38","text":"38(2017), 4, Seite 1741-1750","year":"2017","issue":"4","extent":"4","pages":"1741-1750"},"title":[{"title_sort":"Human brain mapping","title":"Human brain mapping"}],"pubHistory":["1.1993 -"]}],"note":["Published online: 23 December 2016","Gesehen am 11.05.2018"]} | ||
| SRT | |a CHAHINEGEODISRUPTION2016 | ||