Plasmodium sporozoite biology
Plasmodium sporozoite transmission is a critical population bottleneck in parasite life-cycle progression and, hence, a target for prophylactic drugs and vaccines. The recent progress of a candidate antisporozoite subunit vaccine formulation to licensure highlights the importance of sporozoite trans...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[2017]
|
| In: |
Cold Spring Harbor perspectives in medicine
Year: 2017, Jahrgang: 7, Heft: 5 |
| ISSN: | 2157-1422 |
| DOI: | 10.1101/cshperspect.a025478 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1101/cshperspect.a025478 Verlag, Volltext: http://perspectivesinmedicine.cshlp.org/content/7/5/a025478 
|
| Verfasserangaben: | Friedrich Frischknecht, Kai Matuschewski |
| Zusammenfassung: | Plasmodium sporozoite transmission is a critical population bottleneck in parasite life-cycle progression and, hence, a target for prophylactic drugs and vaccines. The recent progress of a candidate antisporozoite subunit vaccine formulation to licensure highlights the importance of sporozoite transmission intervention in the malaria control portfolio. Sporozoites colonize mosquito salivary glands, migrate through the skin, penetrate blood vessels, breach the liver sinusoid, and invade hepatocytes. Understanding the molecular and cellular mechanisms that mediate the remarkable sporozoite journey in the invertebrate vector and the vertebrate host can inform evidence-based next-generation drug development programs and immune intervention strategies. |
|---|---|
| Beschreibung: | Gesehen am 11.05.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 2157-1422 |
| DOI: | 10.1101/cshperspect.a025478 |