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The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders

The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular subgroups. Precision medicine approaches aim to overcome this challenge by combining pa...

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Hauptverfasser: Loth, Eva (VerfasserIn) , Banaschewski, Tobias (VerfasserIn) , Brandeis, Daniel (VerfasserIn) , Bölte, Sven (VerfasserIn) , Meyer-Lindenberg, Andreas (VerfasserIn) , Mößnang, Carolin Ulrike (VerfasserIn) , Tost, Heike (VerfasserIn)
Weitere Verfasser: Baumeister, Sarah (BerichterstatterIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 23 June 2017
In: Molecular autism
Year: 2017, Jahrgang: 8, Pages: 1-19
ISSN:2040-2392
DOI:10.1186/s13229-017-0146-8
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13229-017-0146-8
Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13229-017-0146-8
Volltext
Verfasserangaben:Eva Loth, Tony Charman, Luke Mason, Julian Tillmann, Emily J.H. Jones, Caroline Wooldridge, Jumana Ahmad, Bonnie Auyeung, Claudia Brogna, Sara Ambrosino, Tobias Banaschewski, Simon Baron-Cohen, Sarah Baumeister, Christian Beckmann, Michael Brammer, Daniel Brandeis, Sven Bölte, Thomas Bourgeron, Carsten Bours, Yvette de Bruijn, Bhismadev Chakrabarti, Daisy Crawley, Ineke Cornelissen, Flavio Dell’ Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Jessica Faulkner, Vincent Frouin, Pilar Garces, David Goyard, Hannah Hayward, Lindsay M. Ham, Joerg Hipp, Rosemary J. Holt, Mark H. Johnson, Johan Isaksson, Prantik Kundu, Meng-Chuan Lai, Xavier Liogier D’ardhuy, Michael V. Lombardo, David J. Lythgoe, René Mandl, Andreas Meyer-Lindenberg, Carolin Moessnang, Nico Mueller, Laurence O’Dwyer, Marianne Oldehinkel, Bob Oranje, Gahan Pandina, Antonio M. Persico, Amber N.V. Ruigrok, Barbara Ruggeri, Jessica Sabet, Roberto Sacco, Antonia San José Cáceres, Emily Simonoff, Roberto Toro, Heike Tost, Jack Waldman, Steve C.R. Williams, Marcel P. Zwiers, Will Spooren, Declan G.M. Murphy and Jan K. Buitelaar
Beschreibung
Zusammenfassung:The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular subgroups. Precision medicine approaches aim to overcome this challenge by combining pathophysiologically based treatments with stratification biomarkers that predict which treatment may be most beneficial for particular individuals. However, so far, we have no single validated stratification biomarker for ASD. This may be due to the fact that most research studies primarily have focused on the identification of mean case-control differences, rather than within-group variability, and included small samples that were underpowered for stratification approaches. The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study worldwide that aims to identify and validate stratification biomarkers for ASD.
Beschreibung:Gesehen am 14.05.2018
Beschreibung:Online Resource
ISSN:2040-2392
DOI:10.1186/s13229-017-0146-8

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