Low utility of serum 25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D3 in predicting peripheral Treg and Th17 cell counts in ESRD and renal transplant patients
BACKGROUND: Vitamin D has shown an immune-modulatory effect in different studies. Vitamin D stimulates Tregs and inhibits Th17 cells. The immune-modulatory role of vitamin D in chronic kidney disease (CKD) and renal transplant patients is unclear. We measured whether different serum levels of vitami...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
27 July 2017
|
| In: |
Transplant immunology
Year: 2017, Jahrgang: 43/44, Pages: 3-10 |
| ISSN: | 1878-5492 |
| DOI: | 10.1016/j.trim.2017.07.003 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.trim.2017.07.003
|
| Verfasserangaben: | Mostafa G. Aly, Li Zhu, Rolf Weimer, Gerhard Opelz, Christian Morath, Ruben Kuon, Mohammed Tohamy, Gamal Saadi, Mona Soliman, Walaa Ibrahim, Volker Daniel |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1575173972 | ||
| 003 | DE-627 | ||
| 005 | 20230427042902.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180516s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.trim.2017.07.003 |2 doi | |
| 035 | |a (DE-627)1575173972 | ||
| 035 | |a (DE-576)505173972 | ||
| 035 | |a (DE-599)BSZ505173972 | ||
| 035 | |a (OCoLC)1341009699 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Aly, Mostafa Gaafa |d 1984- |e VerfasserIn |0 (DE-588)1111787026 |0 (DE-627)865894329 |0 (DE-576)476254450 |4 aut | |
| 245 | 1 | 0 | |a Low utility of serum 25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D3 in predicting peripheral Treg and Th17 cell counts in ESRD and renal transplant patients |c Mostafa G. Aly, Li Zhu, Rolf Weimer, Gerhard Opelz, Christian Morath, Ruben Kuon, Mohammed Tohamy, Gamal Saadi, Mona Soliman, Walaa Ibrahim, Volker Daniel |
| 264 | 1 | |c 27 July 2017 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 16.05.2018 | ||
| 520 | |a BACKGROUND: Vitamin D has shown an immune-modulatory effect in different studies. Vitamin D stimulates Tregs and inhibits Th17 cells. The immune-modulatory role of vitamin D in chronic kidney disease (CKD) and renal transplant patients is unclear. We measured whether different serum levels of vitamin D were associated with an increased or decreased presence of lymphocyte subsets including Treg and Th17 cells in end-stage renal disease (ESRD) and renal transplant recipients. METHODS: Eighty-seven renal transplant recipients and 53 end-stage renal disease (ESRD) patients were enrolled in this study. The absolute counts of CD4+ and CD8+ T, CD16+ CD56+ NK, CD19+ B, CD4+ CD25+ CD127- Foxp3+ (Tregs), Helios+ Tregs, CD38+ Tregs, and CD4+ CD17+ (Th17) cells were analyzed in peripheral blood in both patient groups. In addition, serum 25 (OH) D3, 1, 25 (OH)2 D3, IL-6, IL-17, IL-23, and TGF-β1 were measured. The association between lymphocyte subset counts and 1, 25 (OH)2 D3 or 25 (OH) D3 was studied, as was the association between serum IL-6, IL-17, IL-23, or TGF-β1 and 1,25 (OH)2 D3 or 25 (OH) D3. RESULTS: Serum 25 (OH) D3 and 1,25 (OH)2 D3 levels were not independently associated with peripheral CD4+ T, CD19+ B, CD16+ CD56+ NK, Treg, or Th17 cell counts. In contrast to serum 25 (OH) D3, serum1, 25 (OH)2 D3 was positively associated with CD8+ T cells counts in renal transplant recipients. CONCLUSION: Our findings indicate low utility of serum 25 (OH) D3 and 1, 25 (OH)2 D3 levels in predicting a change in lymphocyte subset counts in ESRD and renal transplant patients. | ||
| 650 | 4 | |a 1, 25 (OH)(2) D(3) | |
| 650 | 4 | |a 25 (OH) D(3) | |
| 650 | 4 | |a Adult | |
| 650 | 4 | |a Calcifediol | |
| 650 | 4 | |a Calcitriol | |
| 650 | 4 | |a CD4 Lymphocyte Count | |
| 650 | 4 | |a Cytokines | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Kidney Failure, Chronic | |
| 650 | 4 | |a Kidney Transplantation | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Renal transplantation | |
| 650 | 4 | |a T-Lymphocytes, Regulatory | |
| 650 | 4 | |a Th17 | |
| 650 | 4 | |a Th17 Cells | |
| 650 | 4 | |a Treg | |
| 700 | 1 | |a Zhu, Li |d 1983- |e VerfasserIn |0 (DE-588)1144412781 |0 (DE-627)1004755635 |0 (DE-576)495388947 |4 aut | |
| 700 | 1 | |a Opelz, Gerhard |d 1944- |e VerfasserIn |0 (DE-588)1026480345 |0 (DE-627)726772453 |0 (DE-576)371826527 |4 aut | |
| 700 | 1 | |a Morath, Christian |d 1973- |e VerfasserIn |0 (DE-588)124036155 |0 (DE-627)085595837 |0 (DE-576)293989923 |4 aut | |
| 700 | 1 | |a Kuon, Ruben-Jeremias |d 1984- |e VerfasserIn |0 (DE-588)1021566217 |0 (DE-627)715822497 |0 (DE-576)362763518 |4 aut | |
| 700 | 1 | |a Daniel, Volker |e VerfasserIn |0 (DE-588)1058939513 |0 (DE-627)79784418X |0 (DE-576)166309168 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Transplant immunology |d Amsterdam [u.a.] : Elsevier, 1993 |g 43/44(2017), Seite 3-10 |h Online-Ressource |w (DE-627)324489110 |w (DE-600)2027651-5 |w (DE-576)26442414X |x 1878-5492 |7 nnas |a Low utility of serum 25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D3 in predicting peripheral Treg and Th17 cell counts in ESRD and renal transplant patients |
| 773 | 1 | 8 | |g volume:43/44 |g year:2017 |g pages:3-10 |g extent:8 |a Low utility of serum 25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D3 in predicting peripheral Treg and Th17 cell counts in ESRD and renal transplant patients |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.trim.2017.07.003 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180516 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1058939513 |a Daniel, Volker |m 1058939513:Daniel, Volker |d 910000 |d 911600 |e 910000PD1058939513 |e 911600PD1058939513 |k 0/910000/ |k 1/910000/911600/ |p 11 |y j | ||
| 998 | |g 1021566217 |a Kuon, Ruben-Jeremias |m 1021566217:Kuon, Ruben-Jeremias |d 910000 |d 910400 |e 910000PK1021566217 |e 910400PK1021566217 |k 0/910000/ |k 1/910000/910400/ |p 6 | ||
| 998 | |g 124036155 |a Morath, Christian |m 124036155:Morath, Christian |d 50000 |e 50000PM124036155 |k 0/50000/ |p 4 | ||
| 998 | |g 1026480345 |a Opelz, Gerhard |m 1026480345:Opelz, Gerhard |d 910000 |d 911600 |e 910000PO1026480345 |e 911600PO1026480345 |k 0/910000/ |k 1/910000/911600/ |p 3 | ||
| 998 | |g 1144412781 |a Zhu, Li |m 1144412781:Zhu, Li |d 910000 |d 911600 |e 910000PZ1144412781 |e 911600PZ1144412781 |k 0/910000/ |k 1/910000/911600/ |p 2 | ||
| 998 | |g 1111787026 |a Aly, Mostafa Gaafar |m 1111787026:Aly, Mostafa Gaafar |d 910000 |d 911600 |e 910000PA1111787026 |e 911600PA1111787026 |k 0/910000/ |k 1/910000/911600/ |p 1 |x j | ||
| 999 | |a KXP-PPN1575173972 |e 3009495331 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Aly","given":"Mostafa Gaafa","display":"Aly, Mostafa Gaafa","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Zhu, Li","role":"aut","family":"Zhu","given":"Li"},{"family":"Opelz","given":"Gerhard","roleDisplay":"VerfasserIn","display":"Opelz, Gerhard","role":"aut"},{"given":"Christian","family":"Morath","role":"aut","roleDisplay":"VerfasserIn","display":"Morath, Christian"},{"given":"Ruben-Jeremias","family":"Kuon","role":"aut","display":"Kuon, Ruben-Jeremias","roleDisplay":"VerfasserIn"},{"given":"Volker","family":"Daniel","role":"aut","roleDisplay":"VerfasserIn","display":"Daniel, Volker"}],"title":[{"title_sort":"Low utility of serum 25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D3 in predicting peripheral Treg and Th17 cell counts in ESRD and renal transplant patients","title":"Low utility of serum 25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D3 in predicting peripheral Treg and Th17 cell counts in ESRD and renal transplant patients"}],"recId":"1575173972","language":["eng"],"note":["Gesehen am 16.05.2018"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"name":{"displayForm":["Mostafa G. Aly, Li Zhu, Rolf Weimer, Gerhard Opelz, Christian Morath, Ruben Kuon, Mohammed Tohamy, Gamal Saadi, Mona Soliman, Walaa Ibrahim, Volker Daniel"]},"id":{"eki":["1575173972"],"doi":["10.1016/j.trim.2017.07.003"]},"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"27 July 2017"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1878-5492"],"eki":["324489110"],"zdb":["2027651-5"]},"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1993","publisher":"Elsevier","dateIssuedDisp":"1993-"}],"language":["eng"],"recId":"324489110","note":["Gesehen am 30.08.04"],"disp":"Low utility of serum 25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D3 in predicting peripheral Treg and Th17 cell counts in ESRD and renal transplant patientsTransplant immunology","type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"volume":"43/44","text":"43/44(2017), Seite 3-10","extent":"8","year":"2017","pages":"3-10"},"pubHistory":["1.1993 -"],"title":[{"title_sort":"Transplant immunology","title":"Transplant immunology"}]}],"physDesc":[{"extent":"8 S."}]} | ||
| SRT | |a ALYMOSTAFALOWUTILITY2720 | ||