Biomarkers for cervical cancer screening: the role of p16INK4a to highlight transforming HPV infections
Biomarkers indicating the initiation of neoplastic transformation processes in human papillomavirus (HPV)-infected epithelial cells are moving into the focus of cancer prevention research, particularly for anogenital cancer, including cancer of the uterine cervix. Based on the in-depth understanding...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
09 Jan 2014
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| In: |
Expert review of proteomics
Year: 2012, Jahrgang: 9, Heft: 2, Pages: 149-163 |
| ISSN: | 1744-8387 |
| DOI: | 10.1586/epr.12.13 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1586/epr.12.13 Verlag, Volltext: https://doi.org/10.1586/epr.12.13 
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| Verfasserangaben: | Magnus von Knebel Doeberitz, Miriam Reuschenbach, Dietmar Schmidt, Christine Bergeron |
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| 520 | |a Biomarkers indicating the initiation of neoplastic transformation processes in human papillomavirus (HPV)-infected epithelial cells are moving into the focus of cancer prevention research, particularly for anogenital cancer, including cancer of the uterine cervix. Based on the in-depth understanding of the molecular events leading to neoplastic transformation of HPV-infected human cells, the cyclin-dependent kinase inhibitor p16INK4a turned out to be substantially overexpressed in virtually all HPV-transformed cells. This finding opened novel avenues in diagnostic histopathology to substantially improve the diagnostic accuracy of cervical cancer and its precursor lesions. Furthermore, it provides a novel technical platform to substantially improve the accuracy of cytology-based cancer early-detection programs. Here, we review the molecular background and the current evidence for the clinical utility of the p16INK4a biomarker for HPV-related cancers, and cervical cancer prevention in particular. | ||
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