Mapping degradation signals and pathways in a eukaryotic N-terminome

Summary: Most eukaryotic proteins are N-terminally acetylated. This modification can be recognized as a signal for selective protein degradation (degron) by the N-end rule pathways. However, the prevalence and specificity of such degrons in the proteome are unclear. Here, by systematically examining...

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Bibliographic Details

Main Authors:	Kats, Ilia (Author) , Khmelinskii, Anton (Author) , Kschonsak, Marc (Author) , Huber, Florian (Author) , Knieß, Robert A. (Author) , Bartosik, Anna (Author) , Knop, Michael (Author)
Format:	Article (Journal)
Language:	English
Published:	May 3, 2018
In:	Molecular cell Year: 2018, Volume: 70, Issue: 3, Pages: 488-501.e5
ISSN:	1097-4164
DOI:	10.1016/j.molcel.2018.03.033
Online Access:	Volltext Volltext
Author Notes:	authors Ilia Kats, Anton Khmelinskii, Marc Kschonsak, Florian Huber, Robert A. Knieß, Anna Bartosik, Michael Knop