SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation
Asthma is a chronic condition with unknown pathogenesis, and recent evidence suggests that enhanced airway epithelial chloride (Cl-) secretion plays a role in the disease. However, the molecular mechanism underlying Cl- secretion and its relevance in asthma pathophysiology remain unknown. To determi...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 4, 2012
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| In: |
The journal of clinical investigation
Year: 2012, Jahrgang: 122, Heft: 10, Pages: 3629-3634 |
| ISSN: | 1558-8238 |
| DOI: | 10.1172/JCI60429 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1172/JCI60429
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| Verfasserangaben: | Pinelopi Anagnostopoulou, Brigitte Riederer, Julia Duerr, Sven Michel, Aristea Binia, Raman Agrawal, Xuemei Liu, Katrin Kalitzki, Fang Xiao, Mingmin Chen, Jolanthe Schatterny, Dorothee Hartmann, Thomas Thum, Michael Kabesch, Manoocher Soleimani, Ursula Seidler, and Marcus A. Mall |
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| 245 | 1 | 0 | |a SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation |c Pinelopi Anagnostopoulou, Brigitte Riederer, Julia Duerr, Sven Michel, Aristea Binia, Raman Agrawal, Xuemei Liu, Katrin Kalitzki, Fang Xiao, Mingmin Chen, Jolanthe Schatterny, Dorothee Hartmann, Thomas Thum, Michael Kabesch, Manoocher Soleimani, Ursula Seidler, and Marcus A. Mall |
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| 520 | |a Asthma is a chronic condition with unknown pathogenesis, and recent evidence suggests that enhanced airway epithelial chloride (Cl-) secretion plays a role in the disease. However, the molecular mechanism underlying Cl- secretion and its relevance in asthma pathophysiology remain unknown. To determine the role of the solute carrier family 26, member 9 (SLC26A9) Cl- channel in asthma, we induced Th2-mediated inflammation via IL-13 treatment in wild-type and Slc26a9-deficient mice and compared the effects on airway ion transport, morphology, and mucus content. We found that IL-13 treatment increased Cl- secretion in the airways of wild-type but not Slc26a9-deficient mice. While IL-13-induced mucus overproduction was similar in both strains, treated Slc26a9-deficient mice exhibited airway mucus obstruction, which did not occur in wild-type controls. In a study involving healthy children and asthmatics, a polymorphism in the 3' UTR of SLC26A9 that reduced protein expression in vitro was associated with asthma. Our data demonstrate that the SLC26A9 Cl- channel is activated in airway inflammation and suggest that SLC26A9-mediated Cl- secretion is essential for preventing airway obstruction in allergic airway disease. These results indicate that SLC26A9 may serve as a therapeutic target for airway diseases associated with mucus plugging. | ||
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| 650 | 4 | |a Airway Obstruction | |
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Antiporters | |
| 650 | 4 | |a Asthma | |
| 650 | 4 | |a Bronchitis | |
| 650 | 4 | |a Child | |
| 650 | 4 | |a Chlorides | |
| 650 | 4 | |a Cyclic AMP | |
| 650 | 4 | |a Cystic Fibrosis Transmembrane Conductance Regulator | |
| 650 | 4 | |a Epithelial Cells | |
| 650 | 4 | |a Genetic Predisposition to Disease | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Interleukin-13 | |
| 650 | 4 | |a Ion Transport | |
| 650 | 4 | |a Lung | |
| 650 | 4 | |a Mice | |
| 650 | 4 | |a Mucus | |
| 650 | 4 | |a Th2 Cells | |
| 650 | 4 | |a Tracheitis | |
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