Centrosome amplification in tumorigenesis
With regard to cancer development the centrosome has been the center of attraction of scientists for already more than a 100 years. After the initial assumption that amplified centrosomes and abnormal mitotic arrangements might be a cause of cancer at the beginning of the last century, enormous effo...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 February 2012
|
| In: |
Cancer letters
Year: 2012, Jahrgang: 322, Heft: 1, Pages: 8-17 |
| ISSN: | 1872-7980 |
| DOI: | 10.1016/j.canlet.2012.02.006 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.canlet.2012.02.006
|
| Verfasserangaben: | Simon J. Anderhub, Alwin Krämer, Bettina Maier |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1575503654 | ||
| 003 | DE-627 | ||
| 005 | 20220814145535.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180525s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.canlet.2012.02.006 |2 doi | |
| 035 | |a (DE-627)1575503654 | ||
| 035 | |a (DE-576)505503654 | ||
| 035 | |a (DE-599)BSZ505503654 | ||
| 035 | |a (OCoLC)1341010122 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Anderhub, Simon |d 1981- |e VerfasserIn |0 (DE-588)103158384X |0 (DE-627)736691324 |0 (DE-576)379063808 |4 aut | |
| 245 | 1 | 0 | |a Centrosome amplification in tumorigenesis |c Simon J. Anderhub, Alwin Krämer, Bettina Maier |
| 264 | 1 | |c 14 February 2012 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.05.2018 | ||
| 520 | |a With regard to cancer development the centrosome has been the center of attraction of scientists for already more than a 100 years. After the initial assumption that amplified centrosomes and abnormal mitotic arrangements might be a cause of cancer at the beginning of the last century, enormous efforts have been undertaken to clarify the relevance of centrosome amplification in tumorigenesis. In the meantime, centrosome amplification has been observed in most, both solid and hematological, cancer entities and by now is viewed as a "hallmark" of cancer cells. In this review we summarize basics in centrosome biology and what is known about the emergence of amplified centrosomes. In addition, we discuss how centrosome amplification might cause aneuploidy thereby leading to malignant transformation of cells. Furthermore, we present recent insights into the role of centrosome amplification in tumor formation based on work in model systems. | ||
| 650 | 4 | |a Aneuploidy | |
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Cell Transformation, Neoplastic | |
| 650 | 4 | |a Centrosome | |
| 650 | 4 | |a Chromosomal Instability | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Neoplasms | |
| 650 | 4 | |a Protein-Serine-Threonine Kinases | |
| 650 | 4 | |a Tumor Suppressor Protein p53 | |
| 700 | 1 | |a Krämer, Alwin |e VerfasserIn |0 (DE-588)1067780025 |0 (DE-627)819183431 |0 (DE-576)426900820 |4 aut | |
| 700 | 1 | |a Maier, Bettina |e VerfasserIn |0 (DE-588)136408214 |0 (DE-627)582080452 |0 (DE-576)301004498 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer letters |d Amsterdam [u.a.] : Elsevier Science, 1975 |g 322(2012), 1, Seite 8-17 |h Online-Ressource |w (DE-627)320434796 |w (DE-600)2004212-7 |w (DE-576)261677926 |x 1872-7980 |7 nnas |a Centrosome amplification in tumorigenesis |
| 773 | 1 | 8 | |g volume:322 |g year:2012 |g number:1 |g pages:8-17 |g extent:10 |a Centrosome amplification in tumorigenesis |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.canlet.2012.02.006 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180525 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 136408214 |a Maier, Bettina |m 136408214:Maier, Bettina |d 910000 |d 910100 |e 910000PM136408214 |e 910100PM136408214 |k 0/910000/ |k 1/910000/910100/ |p 3 |y j | ||
| 998 | |g 1067780025 |a Krämer, Alwin |m 1067780025:Krämer, Alwin |d 910000 |d 910100 |e 910000PK1067780025 |e 910100PK1067780025 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 999 | |a KXP-PPN1575503654 |e 3010156537 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Anderhub","role":"aut","given":"Simon","display":"Anderhub, Simon"},{"family":"Krämer","display":"Krämer, Alwin","role":"aut","given":"Alwin"},{"role":"aut","given":"Bettina","display":"Maier, Bettina","family":"Maier"}],"name":{"displayForm":["Simon J. Anderhub, Alwin Krämer, Bettina Maier"]},"id":{"eki":["1575503654"],"doi":["10.1016/j.canlet.2012.02.006"]},"physDesc":[{"extent":"10 S."}],"note":["Gesehen am 25.05.2018"],"relHost":[{"note":["Gesehen am 22.01.2020"],"disp":"Centrosome amplification in tumorigenesisCancer letters","id":{"issn":["1872-7980"],"zdb":["2004212-7"],"eki":["320434796"]},"physDesc":[{"extent":"Online-Ressource"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"320434796","origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedDisp":"1975-","publisher":"Elsevier Science","dateIssuedKey":"1975"}],"pubHistory":["1.1975 -"],"part":{"extent":"10","pages":"8-17","issue":"1","volume":"322","year":"2012","text":"322(2012), 1, Seite 8-17"},"language":["eng"],"title":[{"subtitle":"an international journal providing a forum for original and pertinent contributions in cancer research","title":"Cancer letters","title_sort":"Cancer letters"}]}],"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"14 February 2012"}],"recId":"1575503654","type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"Centrosome amplification in tumorigenesis","title_sort":"Centrosome amplification in tumorigenesis"}],"language":["eng"]} | ||
| SRT | |a ANDERHUBSICENTROSOME1420 | ||