A second combinatorial immune receptor in monocytes/macrophages is based on the TCRγ [delta]
Recent evidence indicates that monocytes and macrophages express T cell receptor (TCR)αβ-like combinatorial immune receptors. Here, we demonstrate the presence of a second recombinatorial immunoreceptor, which is structurally based on the TCR γ- and δ-chains, in human and murine monocytes and differ...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2013
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| In: |
Immunobiology
Year: 2012, Jahrgang: 218, Heft: 7, Pages: 960-968 |
| ISSN: | 1878-3279 |
| DOI: | 10.1016/j.imbio.2012.11.005 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.imbio.2012.11.005 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0171298512005360 
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| Verfasserangaben: | Tina Fuchs, Kerstin Puellmann, Martin Hahn, Claudia Dollt, Ioanna Pechlivanidou, Ilja Ovsiy, Julia Kzhyshkowska, Alexei Gratchev, Julian Fleig, Alexander Emmert, Michael Neumaier, Alexander W. Beham, Wolfgang E. Kaminski |
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| 520 | |a Recent evidence indicates that monocytes and macrophages express T cell receptor (TCR)αβ-like combinatorial immune receptors. Here, we demonstrate the presence of a second recombinatorial immunoreceptor, which is structurally based on the TCR γ- and δ-chains, in human and murine monocytes and differentially activated macrophages (referred to here as TCRLmγδ). In vitro, infection of macrophages with mycobacteria and gram positive or gram negative bacteria induced expression of donor-specific and differential TCRLm Vδ repertoires indicating that the novel immunoreceptor represents a dynamic flexible host defense system that responds to bacterial challenge. In vivo, we find that TCRLmγδ bearing macrophages, which express highly restricted repertoires of the antigen-binding Vδ chain, accumulate in the cerebrospinal fluid in acute bacterial meningitis and in advanced lesions of atherosclerosis. These results identify an as yet unrecognized monocyte/macrophage subpopulation that bears combinatorial TCRLm γδ immune receptors, and is associated with both acute and chronic inflammatory diseases. Moreover, they indicate that the monocytic lineage uses the same bipartite system of TCRαβ/TCRγδ-based combinatorial immune receptors that is present in T cells. Our findings suggest specific roles of monocytes/macrophages in various inflammatory conditions and lend further evidence that flexible immune recognition in higher vertebrates operates on a broader cellular basis than previously thought. | ||
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