Performance of an atlas-based autosegmentation software for delineation of target volumes for radiotherapy of breast and anorectal cancer

BACKGROUND AND PURPOSE: To validate atlas-based autosegmentation for contouring breast/anorectal targets. METHODS AND MATERIALS: ABAS uses atlases with defined CTVs as template cases to automatically delineate target volumes in other patient CT-datasets. Results are compared with manually contoured...

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Hauptverfasser: Anders, Lisanne C. (VerfasserIn) , Stieler, Florian (VerfasserIn) , Siebenlist, Kerstin (VerfasserIn) , Lohr, Frank (VerfasserIn) , Wenz, Frederik (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2012
In: Radiotherapy and oncology
Year: 2012, Jahrgang: 102, Heft: 1, Pages: 68-73
ISSN:1879-0887
DOI:10.1016/j.radonc.2011.08.043
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1016/j.radonc.2011.08.043
Volltext
Verfasserangaben:Lisanne C. Anders, Florian Stieler, Kerstin Siebenlist, Jörg Schäfer, Frank Lohr, Frederik Wenz

MARC

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520 |a BACKGROUND AND PURPOSE: To validate atlas-based autosegmentation for contouring breast/anorectal targets. METHODS AND MATERIALS: ABAS uses atlases with defined CTVs as template cases to automatically delineate target volumes in other patient CT-datasets. Results are compared with manually contoured CTVs of breast/anorectal cancer according to RTOG-guidelines. The impact of using specific atlases matched to individual patient geometry was evaluated. Results were quantified by analyzing Dice Similarity Coefficient (DSC), logit(DSC) and Percent Overlap (PO). DSC >0.700 and logit(DSC) >0.847 are acceptable. In addition a new algorithm (STAPLE) was evaluated. RESULTS: ABAS produced good results for the CTV of breast/anorectal cancer targets. Delineation of inguinal lymphatic drainage, however, was insufficient. Results for breast CTV were (DSC: 0.86-0.91 ([0,1]), logit(DSC): 1.82-2.36 ([-∞,∞]), PO: 75.5-82.89%) and for anorectal CTVA (DSC: 0.79-0.85, logit(DSC): 1.40-1.77, PO: 68-73.67%). CONCLUSIONS: ABAS produced satisfactory results for these clinical target volumes that are defined by more complex tissue interface geometry, thus streamlining and facilitating the radiotherapy workflow which is essential to face increasing demand and limited resources. STAPLE improved contouring outcome. Small target volumes not clearly defined are still to be delineated manually. Based on these results, ABAS has been clinically introduced for precontouring of CTVs/OARs. 
650 4 |a Algorithms 
650 4 |a Atlases as Topic 
650 4 |a Breast Neoplasms 
650 4 |a Female 
650 4 |a Humans 
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650 4 |a Radiotherapy Planning, Computer-Assisted 
650 4 |a Rectal Neoplasms 
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