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Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain

Semaphorins and their receptors are involved in neurodevelopment, but their functions in the adult nervous system are not fully understood. This study finds that semaphorin 4C and its receptor Plexin B are expressed in sensory neurons and are pronociceptive in a mouse model of inflammatory pain.

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Bibliographic Details
Main Authors: Paldy, Eszter (Author) , Simonetti, Manuela (Author) , Bali, Kiran Kumar (Author) , Vicuña Zauschkevich, Lucas (Author) , Kuner, Rohini (Author)
Format: Article (Journal)
Language:English
Published: 02 August 2017
In: Nature Communications
Year: 2017, Volume: 8
ISSN:2041-1723
DOI:10.1038/s41467-017-00341-w
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/s41467-017-00341-w
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-017-00341-w
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Author Notes:Eszter Paldy, Manuela Simonetti, Thomas Worzfeld, Kiran Kumar Bali, Lucas Vicuña, Stefan Offermanns, Rohini Kuner
Description
Summary:Semaphorins and their receptors are involved in neurodevelopment, but their functions in the adult nervous system are not fully understood. This study finds that semaphorin 4C and its receptor Plexin B are expressed in sensory neurons and are pronociceptive in a mouse model of inflammatory pain.
Item Description:Gesehen am 28.05.2018
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-017-00341-w

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