Dephasing and diffusion on the alveolar surface
We propose a surface model of spin dephasing in lung tissue that includes both susceptibility and diffusion effects to provide a closed-form solution of the Bloch-Torrey equation on the alveolar surface. The nonlocal susceptibility effects of the model are validated against numerical simulations of...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 February 2017
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| In: |
Physical review
Year: 2017, Jahrgang: 95, Heft: 2, Pages: 022415 |
| ISSN: | 2470-0053 |
| DOI: | 10.1103/PhysRevE.95.022415 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1103/PhysRevE.95.022415 Verlag, Volltext: https://link.aps.org/doi/10.1103/PhysRevE.95.022415 
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| Verfasserangaben: | L.R. Buschle, F.T. Kurz, T. Kampf, W.L. Wagner, J. Duerr, W. Stiller, P. Konietzke, F. Wünnemann, M.A. Mall, M.O. Wielpütz, H.P. Schlemmer, and C.H. Ziener |
| Zusammenfassung: | We propose a surface model of spin dephasing in lung tissue that includes both susceptibility and diffusion effects to provide a closed-form solution of the Bloch-Torrey equation on the alveolar surface. The nonlocal susceptibility effects of the model are validated against numerical simulations of spin dephasing in a realistic lung tissue geometry acquired from synchotron-based μCT data sets of mouse lung tissue, and against simulations in the well-known Wigner-Seitz model geometry. The free induction decay is obtained in dependence on microscopic tissue parameters and agrees very well with in vivo lung measurements at 1.5 Tesla to allow a quantification of the local mean alveolar radius. Our results are therefore potentially relevant for the clinical diagnosis and therapy of pulmonary diseases. |
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| Beschreibung: | Gesehen am 30.05.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 2470-0053 |
| DOI: | 10.1103/PhysRevE.95.022415 |