Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-α*
Acquired glucocorticoid resistance frequently complicates the therapy of sepsis. It leads to an exaggerated proinflammatory response and has been related to altered expression profiles of glucocorticoid receptor isoforms glucocorticoid receptor-α (mediating anti-inflammatory effects) and glucocortic...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2012/10/01
|
| In: |
Critical care medicine
Year: 2012, Jahrgang: 40, Heft: 10, Pages: 2745-2753 |
| ISSN: | 1530-0293 |
| DOI: | 10.1097/CCM.0b013e31825b8ebc |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1097/CCM.0b013e31825b8ebc Verlag, Volltext: https://journals.lww.com/ccmjournal/Abstract/2012/10000/Corticosteroid_resistance_in_sepsis_is_influenced.1.aspx 
|
| Verfasserangaben: | Carola Ledderose, Patrick Möhnle, Elisabeth Limbeck, Stefanie Schütz, Florian Weis, Jessica Rink, Josef Briegel, Simone Kreth |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1575918692 | ||
| 003 | DE-627 | ||
| 005 | 20230427042920.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180604s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1097/CCM.0b013e31825b8ebc |2 doi | |
| 035 | |a (DE-627)1575918692 | ||
| 035 | |a (DE-576)505918692 | ||
| 035 | |a (DE-599)BSZ505918692 | ||
| 035 | |a (OCoLC)1341010499 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Ledderose, Carola |e VerfasserIn |0 (DE-588)133339114 |0 (DE-627)543376648 |0 (DE-576)299782034 |4 aut | |
| 245 | 1 | 0 | |a Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-α* |c Carola Ledderose, Patrick Möhnle, Elisabeth Limbeck, Stefanie Schütz, Florian Weis, Jessica Rink, Josef Briegel, Simone Kreth |
| 264 | 1 | |c 2012/10/01 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.06.2018 | ||
| 520 | |a Acquired glucocorticoid resistance frequently complicates the therapy of sepsis. It leads to an exaggerated proinflammatory response and has been related to altered expression profiles of glucocorticoid receptor isoforms glucocorticoid receptor-α (mediating anti-inflammatory effects) and glucocorticoid receptor-β (acting as a dominant negative inhibitor). We investigated the impact of glucocorticoid receptor isoforms on glucocorticoid effects in human T-cells. We hypothesized that 1) changes of the ratio of glucocorticoid receptor isoforms impact glucocorticoid resistance and 2) glucocorticoid receptor-α expression is controlled by microRNA-mediated gene silencing. | ||
| 773 | 0 | 8 | |i Enthalten in |t Critical care medicine |d Hagerstown, Md. : Lippincott Williams & Wilkins, 1973 |g 40(2012), 10, Seite 2745-2753 |h Online-Ressource |w (DE-627)325051682 |w (DE-600)2034247-0 |w (DE-576)094425582 |x 1530-0293 |7 nnas |a Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-α* |
| 773 | 1 | 8 | |g volume:40 |g year:2012 |g number:10 |g pages:2745-2753 |g extent:9 |a Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-α* |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1097/CCM.0b013e31825b8ebc |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://journals.lww.com/ccmjournal/Abstract/2012/10000/Corticosteroid_resistance_in_sepsis_is_influenced.1.aspx |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180604 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 133339114 |a Ledderose, Carola |m 133339114:Ledderose, Carola |d 60000 |d 61600 |e 60000PL133339114 |e 61600PL133339114 |k 0/60000/ |k 1/60000/61600/ |p 1 |x j | ||
| 999 | |a KXP-PPN1575918692 |e 301123843X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Carola Ledderose, Patrick Möhnle, Elisabeth Limbeck, Stefanie Schütz, Florian Weis, Jessica Rink, Josef Briegel, Simone Kreth"]},"origin":[{"dateIssuedDisp":"2012/10/01","dateIssuedKey":"2012"}],"id":{"doi":["10.1097/CCM.0b013e31825b8ebc"],"eki":["1575918692"]},"physDesc":[{"extent":"9 S."}],"relHost":[{"title":[{"title_sort":"Critical care medicine","subtitle":"the official journal of the Society of Critical Care Medicine","title":"Critical care medicine"}],"part":{"text":"40(2012), 10, Seite 2745-2753","volume":"40","extent":"9","year":"2012","pages":"2745-2753","issue":"10"},"pubHistory":["1.1973 -"],"corporate":[{"role":"isb","roleDisplay":"Herausgebendes Organ","display":"Society of Critical Care Medicine"}],"language":["eng"],"recId":"325051682","note":["Gesehen am 20.05.19","Fortsetzung der Druck-Ausgabe"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-α*Critical care medicine","id":{"issn":["1530-0293"],"eki":["325051682"],"zdb":["2034247-0"]},"origin":[{"dateIssuedKey":"1973","publisher":"Lippincott Williams & Wilkins ; Ovid","dateIssuedDisp":"1973-","publisherPlace":"Hagerstown, Md. ; [Erscheinungsort nicht ermittelbar]"}],"physDesc":[{"extent":"Online-Ressource"}]}],"person":[{"roleDisplay":"VerfasserIn","display":"Ledderose, Carola","role":"aut","family":"Ledderose","given":"Carola"}],"title":[{"title":"Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-α*","title_sort":"Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-α*"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 04.06.2018"],"language":["eng"],"recId":"1575918692"} | ||
| SRT | |a LEDDEROSECCORTICOSTE2012 | ||